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Recommendations of International Consensus Group on VTE after spine surgeries

Written By : Dr Supreeth D R |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-05-07T09:00:38+05:30  |  Updated On 7 May 2022 9:00 AM IST
Recommendations of International Consensus Group on VTE after spine surgeries
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The International Consensus Meeting (ICM), having recognized the limitations of the current guidelines and the need for unbiased randomized trials with clinically important end points, convened a group of experts from around the globe to generate guidelines or recommendations that address the real-world issues. Delegates from 135 international societies, 68 countries, and various specialties were invited to comb through the literature in a systematic review format and to create practical recommendations related to all subspecialties in orthopedics that would also have global applications. This immense initiative engaged nearly 600 experts who followed the strict Delphi process, as in prior ICM activities to generate the monumental document. Over a period of 1 year, and with the critical guidance of the steering committee and engagement of the organizing committee, librarians, biostatisticians, epidemiologists, and experts from the Cochrane group, ALL published work related to VTE and orthopaedics was reviewed to generate a response/recommendation.

Spine:

1 - Is routine screening for DVT required in the preoperative and/or post-operative period for patients undergoing spine procedures?

There is no role for routine screening for deep venous thrombosis (DVT) in patients undergoing spine procedures. Doppler ultrasonography surveillance may be considered in high-risk surgical patients including those who are older, with spine injury, personal history of VTE, malignancy, cervical spondylotic myelopathy (CSM), and/or non-ambulatory.

2 - Concerning VTE risk, which surgeries can be considered high-risk, and which surgeries can be considered low-risk in spine surgery?

Concerning venous thromboembolism (VTE) risk in spine surgery, high-risk procedures include those performed for oncologic, traumatic, or infection, as well as those requiring intensive care unit (ICU) admission, multiple stages, or combined approaches. Lumbar procedures including long-segment fusions or procedures utilizing an anterior approach, as well as posterior cervical fusions, should also be considered high-risk. On the other hand, most elective pediatric procedures, microdiscectomies, anterior cervical fusions, and lumbar or cervical decompressions may be considered low risk procedure.

3 - Does the concern for epidural hematoma influence the choice for VTE prophylaxis after spine surgery?

Epidural hematoma is a feared yet rare postoperative complication after spinal surgery, with symptomatic rates ranging from 0% to 1.8%. Although there is no published evidence to precisely define the safety of chemoprophylaxis, it seems that postoperative anticoagulants in non-therapeutic doses can be administered without an increased risk of spinal epidural hematoma. Prospective studies are required to better balance the risks and benefits of prophylactic anticoagulants regarding spinal epidural hematomas and venous thromboembolism (VTE).

4 - When can VTE chemoprophylaxis, if to be used, be started following spine procedures?

Venous Thromboembolism (VTE) chemoprophylaxis can probably be started within 24 - 48 hours following elective lumbar fusions, and within 48 hours following patients considered to be higher risk with bleeding. Chemoprophylaxis benefits should be carefully weighed against the risks of bleeding and hematoma formation.

5 - If VTE prophylaxis is to be administered, does the number of levels, and/or the anatomical location, and/ or surgical approach (i.e., minimally invasive) influence the choice of VTE prophylaxis for patients undergoing spinal surgery?

There is some evidence suggesting that chemoprophylaxis should be considered in patients undergoing multi-level lumbar spine surgery, especially when performed through an anterior approach.

6 - Is aspirin a viable chemoprophylaxis for VTE in patients undergoing spine surgery?

While aspirin (ASA) may reduce venous thromboembolism (VTE) after orthopaedic procedures, there are no high-quality studies addressing this issue in patients undergoing spine surgery. We recommend surgeons weigh the potential benefits of chemoprophylaxis with known risks of increased bleeding.

7 - What is the optimal protocol for management of patients who are on aspirin for a non-spine related disorder prior to spine surgery?

Prior to spine surgery, low dose-aspirin (LD-ASA) (81 mg - 500 mg) used for primary and secondary cardiovascular prevention, can be stopped for one to three days. For ASA doses > 1 g per day, ASA should be stopped for at least seven days prior to surgery. However, in patients with extensive cardiac history, it is reasonable to maintain LD-ASA (81 mg) throughout spine surgery.

8 - What is the optimal protocol for management of patients who are being treated with warfarin for a nonspine related disorder prior to spine surgery?

Warfarin (Coumadin) should be discontinued at least 5 days before spine surgery, and the international normalized ratio (INR) goal should be 1.2 or less.

9 - In patients on anticoagulants for a non-spine disorder, is perioperative bridging therapy necessary following cessation of anticoagulation prior to spine surgery?

Perioperative bridging anticoagulation therapy is not superior to placebo in preventing thromboembolic events following cessation of anticoagulation prior to spine surgery. Additionally, bridging anticoagulation therapy can be associated with higher risk of major bleeding. If a bridging therapy is contemplated in high-risk patients, and at the discretion of the treating physician, unfractionated heparin and low-molecular-weight heparin (LMWH) are reasonable options.

10 - Do patients with spine trauma require routine VTE prophylaxis before and after surgery?

Patients suffering from traumatic spine injury are at an increased risk for venous thromboembolism (VTE). Recommendations for VTE prophylaxis before and after surgery in spine trauma varies based on pertinent factors such as presence of spinal cord injury (SCI), segment of the spine involved and age.

11 - Does the presence of a dural tear influence the choice for VTE prophylaxis after spine surgery?

Following spine surgery, the rate of venous thromboembolism (VTE) is significantly higher in patients with incidental durotomy (almost 1.5 times) compared to patients without. Therefore, in patients with dural tears post spine surgery, vigorous VTE prophylaxis therapies should be considered.

12 - Should pediatric patients undergoing major spine procedures require routine VTE prophylaxis?

Routine administration of pharmacologic venous thromboembolism (VTE) prophylaxis for major spinal procedures in pediatric patients is not supported by current evidence. Chemoprophylaxis should be limited to patients with multiple risk factors. Controversy exists on the utility of mechanical prophylaxis although poses minimal risk.

Further reading:

RECOMMENDATIONS FROM THE ICM-VTE AFTER ORTHOPEDIC PROCEDURES

THE JOURNAL OF BONE & JOINT SURGERY

VOLUME 104-A NUMBER 6 (SUPPLEMENT 1) MARCH 16, 2022

SpineJBJSICM-VTE recommendations
Source : Journal of bone and Joint Surgery
Dr Supreeth  D R
Dr Supreeth D R

    MBBS, Dip. Ortho, DNB ortho, MNAMS

    Dr Supreeth D R (MBBS, Dip. Ortho, DNB ortho, MNAMS) is a practicing orthopedician with interest in medical research and publishing articles. He completed MBBS from mysore medical college, dip ortho from Trivandrum medical college and sec. DNB from Manipal Hospital, Bengaluru. He has expirence of 7years in the field of orthopedics. He has presented scientific papers & posters in various state, national and international conferences. His interest in writing articles lead the way to join medical dialogues. He can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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