Allopurinol non-inferior to febuxostat for gout treatment: Study
USA: Allopurinol, when dosed appropriately as part of a treat-to-target strategy, is non-inferior to febuxostat for gout treatment, according to results from a large, randomized double-blind trial. Further, both the urate-lowering therapies (ULTs) were highly effective as 80% of patients achieved and maintained serum urate (SU) goals after 1 year and more than 90% achieved SU < 6.8 mg/dl.
The study findings were presented at the ACR (American College of Rheumatology) Convergence 2021.
Urate lowering therapy is a key treatment for gout management. However, there is a lack of data about the relative safety and efficacy of the two major oral ULTs (febuxostat and allopurinol) when administered as part of a treat-to-target approach as recommended by ACR and EULAR. There is a need for evidence regarding the comparative safety and efficacy in the context of chronic kidney disease (CKD), a common comorbid condition among gout patients.
For this purpose, James O'Dell, University of Nebraska Medical Center, Omaha, NE, and colleagues designed a multicenter, randomized, double-blind, non-inferiority trial to examine the comparative efficacy and safety of these ULTs in gout management.
The study included patients with gout and a serum urate (SU) concentration ≥ 6.8 mg/dl. They were randomized in the ratio of 1:1 to receive appropriately titrated allopurinol or febuxostat in this non-inferiority 72-week trial. Patients with persistent hyperuricemia, despite treatment with allopurinol (≤ 300 mg/dl), were eligible and the protocol specified that ≥ 1/3 would have CKD stage 3. The trial had 3 phases: 1) ULT titration (weeks 0-24), 2) Maintenance (weeks 25-48), and 3) Observation, with continued stable ULT (weeks 49-72). Allopurinol and febuxostat were initiated in daily doses of 100 mg and 40 mg with maximum titration to 800 mg and 120 mg (reduced to 80 mg in 2019 per FDA's request), respectively. According to 2012 ACR guidelines, patients received anti-inflammatory prophylaxis hosen by the site investigator until the beginning of phase 3.
The primary endpoint was the proportion of patients experiencing ≥ 1 flare during phase 3 with a pre-specified margin of < 8% difference indicative of non-inferiority. Secondary endpoints included: efficacy/tolerability in CKD stage 3, the proportion achieving SU < 6 mg/dl at the end of phase 2, and serious adverse events (SAE).
Key findings include:
- Characteristics of the 940 patients with gout (n=21 sites) receiving at least 1 dose of study medication.
- Overall, 20% withdrew prior to completion with similar proportions by treatment arm.
- During phase 3, 35% of patients treated with allopurinol had ≥ 1 flare compared to 42% of participants treated with febuxostat.
- 80% of patients achieved SU < 6.0 mg/dl (92% achieved SU < 6.8 mg/dl) during phase 2 with no difference according to ULT treatment.
- There were no treatment differences in SAEs (including percent of patients with cardiovascular events) in those with or without CKD.
"There was no evidence of increased cardiovascular toxicity with febuxostat compared to allopurinol," the researchers wrote. "Moreover, the comparative efficacy and safety of these two agents extended to patients with CKD stage 3, highly relevant as nearly one in every two gout patients suffers from renal insufficiency."
Reference:
O'Dell J, Neogi T, Pillinger M, Palevsky P, Newcomb J, Brophy M, Wu H, Davis-Karim A, Ferguson R, Pittman D, Terkeltaub R, Cannella A, England B, Helget L, Mikuls T, Taylor T. Urate Lowering Therapy in the Treatment of Gout: A Multicenter, Randomized, Double-blind Comparison of Allopurinol and Febuxostat Using a Treat-to-Target Strategy [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 10). https://acrabstracts.org/abstract/urate-lowering-therapy-in-the-treatment-of-gout-a-multicenter-randomized-double-blind-comparison-of-allopurinol-and-febuxostat-using-a-treat-to-target-strategy/. Accessed November 16, 2021.
