Bilateral oophorectomy Increase Risk of Carpal Tunnel Syndrome, reveals study

Written By : Dr Kartikeya Kohli |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-09-17T09:00:37+05:30 | Updated On 17 Sept 2021 9:01 AM IST

The prevalence of carpal tunnel syndrome (CTS) is up to 3 to 5% in the general population, predominantly in the female population. A recent study suggests that the risk of severe CTS increases with bilateral oophorectomy. The study findings were published in the journal Menopause.

The incidence of carpal tunnel syndrome (CTS) is higher in women and peaks around the age of menopause. Therefore, Dr Starlinger, Julia and her team conducted a study to investigate whether bilateral oophorectomy is associated with an increased risk of severe CTS.

In this population-based cohort study, the researchers included a total of 1,653 premenopausal women who underwent bilateral oophorectomy for a nonmalignant indication between 1988 and 2007. They also included a random sample of 1,653 age-matched referent women who did not undergo bilateral oophorectomy. They evaluated the diagnoses of CTS assigned to women over their entire lifetime in these two cohorts. They used Cox proportional hazards models adjusted for potential confounders to evaluate the risk of de novo severe CTS after bilateral oophorectomy.

Key findings of the study were:

Upon analysis, the researchers found that bilateral oophorectomy was associated with an increased risk of severe CTS (adjusted hazard ratio 1.65).
They also found that the risk was higher in women with lower body mass index, nulliparity, and with a benign ovarian indication for oophorectomy (nonsignificant interactions).
They observed no protective effect of estrogen therapy after the oophorectomy.
They noted that the findings were similar in secondary analyses considering the incidence of CTS of any severity or idiopathic CTS.

The authors concluded, "The risk of severe CTS, common in perimenopausal women, is increased after bilateral oophorectomy. The association may be causal or due to confounding. Therefore, the precise biological mechanisms explaining the association and the absence of a mitigating effect of estrogen therapy should be further investigated."

For further information:

doi: 10.1097/GME.0000000000001804

Menopausesevere carpal tunnel syndromebilateral oophorectomyEstrogen therapyBenign ovarian conditionperimenopausal womenStarlinger Julia

Article Source : Menopause

Dr Kartikeya Kohli

Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751