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  • Limiting alcohol...

Limiting alcohol intake may influence likelihood of developing MTX-related adverse events

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-11-17T09:00:21+05:30  |  Updated On 17 Nov 2021 9:00 AM IST
Limiting alcohol intake may influence likelihood of developing MTX-related adverse events
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Methotrexate (MTX) is known to induce side effects like nausea and alopecia.Limiting alcohol consumption may influence likelihood of developing MTX-related adverse events according to a new study presented at ACR Convergence 2021.

Methotrexate (MTX) is the first-line treatment in the management of patients with rheumatoid arthritis (RA) due to its good efficacy. However, certain adverse events, such as nausea and alopecia, often create considerable concerns to patients starting the treatment and could affect their quality of life. This may result in non-adherence to MTX or permanent discontinuation of treatment in the early period following the start of MTX. This study aimed to summarise the prevalence rates of nausea and alopecia, and identify baseline factors associated with the development of these adverse events over the first year of MTX treatment. The Rheumatoid Arthritis Medication Study (RAMS) is a multi-centre prospective cohort study of patients with RA commencing MTX for the first time. Relevant demographic, clinical and medication-related data were collected at baseline (Table). Adverse events were reported at six- and twelve-month follow-ups. The prevalence rates of nausea and alopecia were calculated based on the proportions of patients who reported having an adverse event within one year of follow-up. Multivariable logistic regression analyses were performed to assess the associations between candidate baseline predictors and nausea or alopecia.

The results of the study are as follows:

  • A total of 1069 patients with early RA were included in this analysis.
  • The mean age at the start of MTX was 59.2 (SD: 13.5) years, 65.3% were women, and the mean duration of symptom was 7.7 (SD: 5.6) months.
  • Around one third of the patients (31.1%) reported nausea over the first year of treatment with MTX. Alopecia was reported by 83 patients (7.8%).
  • Women were more likely to report nausea and alopecia compared with men, odds ratios (ORs) were 2.22 and 3.93 respectively
  • Older age was associated with decreased odds of reporting nausea, OR 0.97
  • Alcohol consumption was associated with increased odds of developing nausea and alopecia, ORs were 1.44 and 1.98, respectively.
  • Higher Disease Activity Score and Belief about Medication Questionnaire – Concern scale at baseline were associated with increased odds of nausea.
  • The use of concomitant csDAMRDs with MTX at baseline was associated with less reporting of nausea and alopecia.

Thus, the researchers concluded that Identifying factors associated with adverse event occurrence could help alleviate patients' concerns and improve adherence to MTX. Limiting alcohol consumption may influence the likelihood of developing MTX-related adverse events.

Reference:

Baseline Factors Associated with the Development of Nausea and Alopecia over One Year in Patients Starting Methotrexate for Rheumatoid Arthritis by

Ahmad Sherbini et al. presented at ACR Convergence 2021.

adverse eventsdisease-modifying antirheumatic drugs (dmards)pharmacoepidemiologyrheumatoid arthritisrisk factorsACR Meeting Abstractsconferencewomenalcohol drinkersMethotrexatenausea or alopecia
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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