- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Multiple serum urate testing not superior to single test for gout prediction over time: Study
New Zealand: A longitudinal study by Sarah Stewart and the team revealed that there is no added significance of repeated serum urate testing compared to a single measurement to predict incidents of gout over time. The results of the study could help in clinical practice when providing advice to individuals about their risk of developing gout.
The study findings were presented at the American College of Rheumatology (ACR) Convergence 2021, held virtually from November 3 to 10, 2021.
Uric acid is a beneficiary diagnostic tool for screening most purine metabolic disorders. Clinicians and researchers consider serum uric acid concentration as a very important diagnostic and prognostic factor of many multifactorial disorders. While elevated serum urate is a key risk factor for incidents of gout, most patients with high serum urate levels will not develop inflammatory arthritis. Furthermore, some patients with normal urate levels do develop gout.
Against the above background, Sarah Stewart, University of Auckland, Auckland, New Zealand, and the team aimed to examine whether single or repeated testing of serum urate more accurately predicts incident gout over time.
The study was a longitudinal cohort study Individual participant data were included from three publicly available cohorts. Data from paired serum urate measures 3-5 years apart, followed by an assessment of gout incidence 5-6 years from the second urate measure were used to calculate the predictive ability of four models of serum urate measurement on incident gout: the first measure, the second measure, the average of the two measures, and the highest of the two measures. Receiver operator characteristic (ROC) curves and area under the curve (AUC) statistics were computed to compare the four models.
A total of 16,017 participants were included across the three cohorts. Overall, 56% of participants were female, and 80% were European. The mean age was 49 years. The mean follow-up from the first serum urate test was 9.3 years.
The results of the study were
• There was a small increase in the mean serum urate between the first and second (5.42 mg/dL vs. 5.71 mg/dL) were a mean of 3.5 years apart, but the first and second measures were highly correlated (r = 0.81).
• No differences were observed in the predictive ability of incident gout between the four measures of serum urate measurement with ROC curve AUC statistics ranging between 0.81 to 0.84
Stewart and the team concluded that "Repeat serum urate testing is not superior to a single measure of serum urate for prediction of incident gout over approximately one decade. These results may inform the design of longitudinal studies of incident gout, and clinical practice when providing advice to individuals about their risk of developing gout."
Reference: Stewart S, Phipps-Green A, Gamble G, Stamp L, Taylor W, Neogi T, Merriman T, Dalbeth N. Is Repeat Serum Urate Testing Superior to a Single Test to Predict Incident Gout over Time? [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 10). https://acrabstracts.org/abstract/is-repeat-serum-urate-testing-superior-to-a-single-test-to-predict-incident-gout-over-time/. Accessed November 25, 2021.
Medical Dialogues consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751