Neuropathic Pain Worsens Disease Severity in Psoriatic Arthritis Patients

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-02-13T07:00:46+05:30 | Updated On 13 Feb 2024 10:07 AM IST

In a recent study published in the Frontiers in Medicine underscore the significant impact of neuropathic pain (NP) on disease activity assessment in patients with psoriatic arthritis (PsA).

This study was conducted as a cross-sectional analysis which involved a total of 246 PsA patients and excluded the individuals with prior diagnoses of fibromyalgia, depression, anxiety, diabetes or dyslipidemia under treatment. Utilizing the painDETECT questionnaire Esther Toledano and team identified NP in 17.1% of the participants.

The results revealed several correlations in which the patients with NP showed higher levels of leptin. Leptin is commonly associated with obesity which indicates a potential link between NP and metabolic health. Also, poor sleep quality was significantly associated with NP that suggests a bidirectional relationship between sleep disturbances and neuropathic pain.

Fatigue levels were markedly higher in patients with NP when compared to those without by indicating the debilitating impact of NP on daily functioning. NP was found to be correlated with worse disease activity as measured by the clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA) by highlighting the need for comprehensive pain management strategies in PsA patients.

This study emphasized the importance of recognizing and addressing NP in PsA management by underscoring the complex relationship between pain, comorbidities and disease severity in Psoriatic Arthritis patients. This research provides valuable insights into the multifaceted nature of pain in PsA and calls for an inclusive approach to patient care. Addressing neuropathic pain and its related factors will help healthcare providers to potentially enhance the quality of life and overall outcomes for individuals with Psoriatic Arthritis.

Source:

Toledano, E., Queiro, R., Gómez-Lechón, L., Chacón, C. C., Hidalgo, C., Ibañez, M., Díaz-Álvarez, A., & Montilla, C. (2024). Influence of comorbidities not associated with fibromyalgia on neuropathic pain in patients with psoriatic arthritis: relationship with clinical parameters. In Frontiers in Medicine (Vol. 11). Frontiers Media SA. https://doi.org/10.3389/fmed.2024.1331761

Frontiers in Medicineneuropathic painPsoriatic arthritis

Source : Frontiers in Medicine

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751