Osteoarthritis associated with higher Parkinson's disease risk: Study
Taipei, Taiwan: Patients with osteoarthritis (OA) are at a increased risk of developing Parkinson's disease (PD), finds a recent study. The findings of the study ae published in the journal Arthritis Care & Research.
Shin-Liang Pan, National Taiwan University, Taipei, Taiwan, and colleagues aimed to investigate whether patients with osteoarthritis are at a higher risk of developing Parkinson's disease.
For the purpose, the researchers conducted retrospective study using Taiwan's Longitudinal Health Insurance Database 2005 included 33,360 patients who were 50-64 years old and had osteoarthritis in 2002-2005. A comparison group consisted of 33,360 age- and sex- matched individuals without osteoarthritis.Their PD-free survival curves were generated using the Kaplan-Meier method.
Key findings of the study include:
- Of the two groups, the OA group had a significantly higher risk of developing PD (adjusted hazard ratio [aHR]=1.41).
- The PD-free survival rate of the OA group was also significantly lower than that of the comparison group.
- The subgroup analysis showed that patients with knee or hip OA appeared to have a higher magnitude of PD risk (aHR 1.55) than patients with non-knee and non-hip OA (aHR 1.42) or with uncategorized OA (aHR 1.32).
Although the mechanisms behind a potential link between osteoarthritis and Parkinson's disease are unknown, both conditions involve inflammation.
"Coexisting osteoarthritis and Parkinson's disease can additively increase the risk of falling. Moreover, osteoarthritis-related mobility impairments may mask early motor symptoms of Parkinson's disease," said senior author Shin-Liang Pan, MD, PhD, of National Taiwan University. "Health professionals need to be alert to the potential link between these two diseases."
The study titled, "Osteoarthritis is associated with an increased risk of Parkinson's disease: A population-based, longitudinal follow-up study," is published in the journal Arthritis Care & Research.