RA linked to Increased Pulmonary Function Abnormalities, claims study
Rheumatoid arthritis (RA) is associated with an increased risk for restrictive and obstructive pattern abnormalities on spirometry, which were not explained by confounding factors such as smoking reports a recent Study.
The study results have been published in Arthritis & Rheumatology.
Researchers under Lauren Prisco, from the Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, USA, investigated the independent relationship of rheumatoid arthritis (RA) with type and severity of pulmonary patterns on spirometry compared to general population controls.
The study was designed as a cross-sectional one investigating the association of RA and pulmonary function measures on spirometry among subjects who had spirometry performed for research purposes in the UK Biobank. RA cases were identified by self-report and current DMARD/glucocorticoid use. General population controls denied RA. Outcomes included continuous % predicted forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), type of spirometric pattern (restrictive or obstructive), and severity. We used multivariable regression to estimate the effects of RA cases versus controls, adjusting for age, sex, body mass index (BMI), and smoking status/pack-years.
Results highlighted some key facts.
· Among 350,776 analyzed subjects with spirometry performed (mean age 56.3 years, 55.8% female, and 45.5% ever smokers), we identified 2,008 cases of treated RA. In multivariable analyses, RA was associated with lower % predicted FEV1 (β -2.93, 95%CI -3.63,-2.24), % predicted FVC (β -2.08, 95%CI -2.72,-1.45), and FEV1/FVC (β -0.008, 95%CI -0.010,-0.005) than controls.
· RA was associated with restrictive (OR 1.36, 95%CI 1.21,1.52) and obstructive (OR 1.21, 95%CI 1.07,1.37) patterns independent of confounders. RA had the strongest associations for severe restrictive and obstructive patterns.
"RA was associated with increased odds of restrictive and obstructive patterns, and this relationship was not explained by confounders including smoking. In addition to restrictive lung disease, clinicians should also be aware that airflow obstruction may be a pulmonary manifestation of RA." the research team opined.
For full article follow the link: https://doi.org/10.1002/art.41791
Source: Arthritis & Rheumatology