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Vitamin D and Omega-3 fatty acids supplementation reduce autoimmune disease risk: Study
![Vitamin D and Omega-3 fatty acids supplementation reduce autoimmune disease risk: Study Vitamin D and Omega-3 fatty acids supplementation reduce autoimmune disease risk: Study](https://medicaldialogues.in/h-upload/2024/01/08/750x450_229511-vitamin-d-may-cut-older-adult-heart-attack-risk-1440x810.webp)
The results of the 5.3-year VITAL trial published in the journal of Arthritis & Rheumatology unveiled the potential of vitamin D and omega-3 fatty acids in combating autoimmune diseases (AD).
The latest findings from the Vitamin D and Omega-3 Trial (VITAL) have highlighted significant insights of the role of vitamin D and omega-3 fatty acids in preventing autoimmune diseases. This double-blind, placebo-controlled study was conducted over 5.3 years and showed compelling evidence of the efficacy of these supplements in reducing AD incidence.
The study reported that vitamin D supplementation showed a notable reduction in autoimmune disease incidence, with a hazard ratio (HR) of 0.78. Despite the omega-3 fatty acid supplementation showing a statistically nonsignificant reduction, it also hinted at potential benefits with a HR of 0.85.
To further validate these findings and assess sustained effects, the team led by Karen Costenbader continued to monitor participants for two years post-intervention. The initial cohort comprised over 25,000 participants, of which 21,592 were observed during this extended period.
During the follow-up, a total of 514 participants developed confirmed autoimmune diseases that reaffirms the significance of the study. Also, while the protective effects of 2000 IU/day of vitamin D seemed to dissipate after two years, the impact of 1000 mg/day of omega-3 fatty acids was observed sustained.
These findings mark a significant milestone in autoimmune disease research that offers valuable insights into preventive measures and treatment avenues. The comprehensive approach of the study combined long-term observation and rigorous analysis that aided in underscoring the importance of continued investigation into the potential benefits of vitamin D and omega-3 supplementation.
This study underscores the potential of omega-3 fatty acids as a sustainable intervention for reducing autoimmune disease incidence. While further research is imperative, these results offer hope for the individuals at risk of developing autoimmune conditions.
Reference:
Costenbader, K. H., Cook, N. R., Lee, I., Hahn, J., Walter, J., Bubes, V., Kotler, G., Yang, N., Friedman, S., Alexander, E. K., & Manson, J. E. (2024). Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind, Placebo‐Controlled Trial. In Arthritis & Rheumatology. Wiley. https://doi.org/10.1002/art.42811
Neuroscience Masters graduate
Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751