Bisotab (Bisoprolol Fumarate Tablets) is a angiotensin II receptor blocker (ARB) used in the therapy of hypertension, Angina Pectoris, and Congestive Heart Failure. Bisotab is marketed by JB Chemical and Pharmaceuticals limited and comes in two doses namely Bisotab 2.5 mg and Bisotab 5 mg.
Bisoprolol is indicated in the treatment of many conditions including Blood Pressure management, Angina Pectoris and Congestive heart failure. Bisoprolol is a potent highly beta1-selective-adrenoceptor blocking agent, lacking intrinsic sympathomimetic and relevant membrane stabilising activity. As with other Beta1blocking agents, the method of acting in hypertension is unclear. However, it is known that Bisoprolol reduces plasma renin activity markedly.
With regards to its antianginal mechanism, Bisoprolol by inhibiting the cardiac beta receptors inhibits the response given to sympathetic activation. That results in the decrease of heart rate and contractility this way decreasing the oxygen demand of the cardiac muscle.