Bizfer XT is a combination of Ferrous Bis-Glycinate 60mg, Folic Acid IP 1mg, Zinc Bis-Glycinate 15 mg & Methylcobalamin IP 500 mcg tablets.
Ferrous Bis-Glycinate consists of one molecule of ferrous iron bound to two molecules of glycine with coordinate covalent bonds which protects the iron from dietary inhibitors as well as doesn’t allow its interaction with GI mucosa hence least GI irritation. Glycine, which is used for chelation is the smallest amino acid. The resultant Ferrous Bis-Glycinate also has low molecular weight which ensures intact absorption. The advantage of Ferrous bisglycinate over other sources of supplemental iron is that its greater bioavailability i.e. 90.9%, into the mucosal cells results in more iron being quickly and safely delivered to target tissues of the body in times of need. This potentially allows for smaller doses of supplemental iron, which can result in fewer gastric complaints and reduced risk of iron overload. Also the solubility of Ferrous Bis-Glycinate is not affected by change in pH (ph 2 – pH 6). This leads to upto 4 times better absorption than other irons. Ferrous bisglycinate chelate was developed to provide a safer product with improved bioavailability.
Folate is a water-soluble vitamin. Folate is critically important for fetal growth and, for this reason, it is required in increased amounts during pregnancy. It is recommended that all women capable of becoming pregnant consume folate in order to reduce the risk of the foetus developing a neural tube defect.
Zinc Bis-Glycinate is a type of zinc supplement. It contains zinc that’s been attached to a chelating agent that bond with metal ions (such as zinc) to create a stable, water-soluble product that can be easily absorbed by the body. Features of zinc deficiency include growth retardation and defects of rapidly dividing tissues such as the skin and the intestinal mucosa.
Methylcobalamin is used for the treatment of vitamin B12 deficiency. Vitamin B12 is very important for the brain and nerves and for the production of red blood cells. The medication is used in people with pernicious anaemia, diabetes and other conditions. It also prevents risk of hyperhomocysteinemia during pregnancy.
• Ferrous bisglycinate is a potentially valuable therapeutic agent for the treatment of iron deficiency anaemia with better efficacy and safety when compared to ferrous sulphate as increase in Hb in ferrous bisglycinate group was higher (22.72%) with lesser side effects (7.8%- constipation, 8.9%- nausea).
• Oral Ferrous bisglycinate can be considered as the best effective medication with tolerable side effects for treatment as well as prevention of iron deficiency anaemia during pregnancy when compared with IV iron (Ferric hydroxide saccharate complex) where myalgia and allergic reaction were significantly noticed.