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Ferrous-Bis-glycinate-Bizfer XT

Bizfer XT is a combination of Ferrous Bis-Glycinate 60mg, Folic Acid IP 1mg, Zinc Bis-Glycinate 15 mg & Methylcobalamin IP 500 mcg tablets.


Ferrous Bis-Glycinate consists of one molecule of ferrous iron bound to two molecules of glycine with coordinate covalent bonds which protects the iron from dietary inhibitors as well as doesn’t allow its interaction with GI mucosa hence least GI irritation. Glycine, which is used for chelation is the smallest amino acid. The resultant Ferrous Bis-Glycinate also has low molecular weight which ensures intact absorption. The advantage of Ferrous bisglycinate over other sources of supplemental iron is that its greater bioavailability i.e. 90.9%, into the mucosal cells results in more iron being quickly and safely delivered to target tissues of the body in times of need. This potentially allows for smaller doses of supplemental iron, which can result in fewer gastric complaints and reduced risk of iron overload. Also the solubility of Ferrous Bis-Glycinate is not affected by change in pH (ph 2 – pH 6). This leads to upto 4 times better absorption than other irons. Ferrous bisglycinate chelate was developed to provide a safer product with improved bioavailability.


Folate is a water-soluble vitamin. Folate is critically important for fetal growth and, for this reason, it is required in increased amounts during pregnancy. It is recommended that all women capable of becoming pregnant consume folate in order to reduce the risk of the foetus developing a neural tube defect.


Zinc Bis-Glycinate is a type of zinc supplement. It contains zinc that’s been attached to a chelating agent that bond with metal ions (such as zinc) to create a stable, water-soluble product that can be easily absorbed by the body. Features of zinc deficiency include growth retardation and defects of rapidly dividing tissues such as the skin and the intestinal mucosa.


Methylcobalamin is used for the treatment of vitamin B12 deficiency. Vitamin B12 is very important for the brain and nerves and for the production of red blood cells. The medication is used in people with pernicious anaemia, diabetes and other conditions. It also prevents risk of hyperhomocysteinemia during pregnancy.

Overview
Name of Product: BIZFER XT Tablets
Marketed by : J.B. Chemicals & Pharmaceuticals Ltd.
Medicine composition: Each film coated tablet of BIZFER XT Tablet contains:
Ferrous Bis-glycinate
Equivalent to Elemental Iron.................................60 mg.
Folic Acid IP .............................................................1mg
Zinc Bis-glycinate
Equivalent to Elemental Zinc................................15 mg.
Methylcobalamin IP...........................................500 mcg.
Excipients...................................................................Q.S.
Colour: Lake of Erythrocine & Sunset yellow
Prescription vs.OTC: Prescription by Doctor required
Dosage Form: Tablet for oral use

Bizfer XT is indicated for the prevention and treatment of nutritional deficiency anaemia related to iron and folic acid.

The dosage of Bizfer XT is one tablet per day, or as directed by the physician.

Bizfer XT is contraindicated in patients hypersensitive to ferrous bisglycinate, folic acid, zinc or to any other component of this formulation.

Notify your doctor if you are on any medication including both over the counter medication or prescription drugs, vitamin supplements and any herbal products before you begin using Bizfer XT. Bizfer XT is known to interact with a number of medicines and products. Interactions might lower the effectiveness of the medication, increase chances of side effects occurring or worsen an existing condition.


Pregnancy

Nutritional supplement doses of vitamins and minerals are generally considered safe during pregnancy.

Do not exceed the recommended dose. The type of anaemia and the underlying cause or causes should be determined before starting therapy with this medication. Since the anaemia may be a result of a systemic disturbance, such as recurrent blood loss, the underlying cause or causes should be corrected, if possible


In general, people with a history of kidney disease, intestinal disease, peptic ulcer disease, enteritis, colitis, pancreatitis, hepatitis, who consume excessive alcohol, who plan to become pregnant, or who have a family history of heart disease should consult a doctor and pharmacist before taking iron.

SIDE EFFECTS


Adverse reactions with iron therapy may include constipation, diarrhoea, nausea, vomiting, dark stools and abdominal pain. Adverse reactions with iron therapy are usually transient. Gastrointestinal side effects are relatively common and corrective bowel regimens such as increasing dietary fibre or over-the-counter medications might be recommended to balance these side effects. Ferrous bisglycinate shows lesser gastrointestinal side effects as compared to other ferrous salts.


OVERDOSAGE


The clinical course of acute iron over dosage can be variable. Initial symptoms may include abdominal pain, nausea, vomiting, diarrhoea, tarry stools, melena, haematemesis, hypotension, tachycardia, metabolic acidosis, hyperglycaemia, dehydration, drowsiness, pallor, cyanosis, lassitude, seizures, shock and coma.

Except during pregnancy and lactation, folic acid should not be given in therapeutic doses greater than 0.4 mg daily until pernicious anaemia has been ruled out.

Acute zinc toxicity after oral ingestion causes nausea and vomiting, fever, and respiratory distress. Chronic large doses of zinc may depress immune function and cause hypochromic anaemia as a result of copper deficiency.

PHARMACODYNAMICS

Iron salts are compounds used primarily for the prophylaxis and treatment of iron deficiency anaemia. The body stores iron in compounds called ferritin and hemosiderin since it is an essential component in the formation of haemoglobin. Adequate amounts of iron are necessary for effective erythropoiesis. Iron also serves as a cofactor of several essential enzymes, including cytochromes, all of which are involved in electron transport. Iron absorption is a variable of the existing body iron stores, the form and quantity in foods, and the combination of foods in the diet. The ferrous form of inorganic iron is more readily absorbed.

Folic acid is required for synthesis of nucleoprotein, purine nucleotides and the metabolism of some amino acids, normal growth and cell reproduction, nucleoprotein synthesis and the maintenance of normal erythropoiesis.

Zinc supplementation improves immunity.

Methylcobalamin (Mecobalamin, MeCbl), is one of the two biologically active vitamin B12.

PHARMACOKINETICS

Iron

The absorption of iron from ferrous bisglycinate is regulated through the same physiological mechanisms as other inorganic forms of iron. Following oral administration, ferrous bisglycinate adds to the intestinal intraluminal pool of inorganic, non-haem iron and is absorbed intact into the mucosal cells of the intestine, and is subsequently hydrolysed into its iron and glycine components with the rates of transfer to the serosa from the mucosal tissue being different for each component. Ferrous bisglycinate chelate is not affected by food ligands. Furthermore, following dissociation from ferrous bisglycinate, the free amino acid, glycine, will enter into normal metabolic processes. The majority of iron loss has been reported to be a consequence of faecal excretion.

Folic Acid

The first metabolic step is the reduction of folic acid in hepatocytes via dihydrofolate reductase to dihydrofolate and subsequently to tetrahydrofolate (THF). THF is further converted to methylene-THF by serine-hydroxymethyltransferase and reduced to physiologically active L-5-MTHF via methylenetetrahydrofolate reductase (MTHFR). MTHFR is subject to genetic polymorphism, and a mutation resulting in low activity of MTHFR involves the risk of elevated homocysteine plasma levels and a higher incidence of foetal neural tube defects during pregnancy. Folic acid and its degradation products are eliminated via urinary excretion (~62%) and to a lesser extent via faeces (~38%).

Zinc

Absorption is pH-dependent; poor from GI tract (20% to 30%); solubilised by conversion to zinc chloride in the presence of gastric acid. Storage sites are liver and skeletal muscle; serum levels do not adequately reflect whole-body zinc status. Excreted 90% in faeces with only traces appearing in urine and perspiration.

Methylcobalamin

Evidence indicates methylcobalamin is utilised more efficiently than cyanocobalamin to increase levels.

Contact us for further information

Bizfer XT is a combination of Ferrous Bis-Glycinate 60mg, Folic Acid IP 1mg, Zinc Bis-Glycinate 15 mg & Methylcobalamin IP 500 mcg tablets.


Ferrous Bis-Glycinate consists of one molecule of ferrous iron bound to two molecules of glycine with coordinate covalent bonds which protects the iron from dietary inhibitors as well as doesn’t allow its interaction with GI mucosa hence least GI irritation. Glycine, which is used for chelation is the smallest amino acid. The resultant Ferrous Bis-Glycinate also has low molecular weight which ensures intact absorption. The advantage of Ferrous bisglycinate over other sources of supplemental iron is that its greater bioavailability i.e. 90.9%, into the mucosal cells results in more iron being quickly and safely delivered to target tissues of the body in times of need. This potentially allows for smaller doses of supplemental iron, which can result in fewer gastric complaints and reduced risk of iron overload. Also the solubility of Ferrous Bis-Glycinate is not affected by change in pH (ph 2 – pH 6). This leads to upto 4 times better absorption than other irons. Ferrous bisglycinate chelate was developed to provide a safer product with improved bioavailability.


Folate is a water-soluble vitamin. Folate is critically important for fetal growth and, for this reason, it is required in increased amounts during pregnancy. It is recommended that all women capable of becoming pregnant consume folate in order to reduce the risk of the foetus developing a neural tube defect.


Zinc Bis-Glycinate is a type of zinc supplement. It contains zinc that’s been attached to a chelating agent that bond with metal ions (such as zinc) to create a stable, water-soluble product that can be easily absorbed by the body. Features of zinc deficiency include growth retardation and defects of rapidly dividing tissues such as the skin and the intestinal mucosa.


Methylcobalamin is used for the treatment of vitamin B12 deficiency. Vitamin B12 is very important for the brain and nerves and for the production of red blood cells. The medication is used in people with pernicious anaemia, diabetes and other conditions. It also prevents risk of hyperhomocysteinemia during pregnancy.

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