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bizfer

Page Created On : 21 Sept 2020 6:54 AM GMT , Page Last Updated On : 9 Oct 2021 10:32 AM GMT

About

Ferrous Bis-Glycinate, Folic Acid IP, Zinc Bis-Glycinate and Methylcobalamin are used as a combination in the medicine for the prevention and treatment of nutritional deficiency anaemia related to iron and folic acid.It is manufactured and sold in India by orofer XT and Bizfer XT

Ferrous Bis-Glycinate consists of one molecule of ferrous iron bound to two molecules of glycine with coordinate covalent bonds which protects the iron from dietary inhibitors as well as doesn’t allow its interaction with GI mucosa hence least GI irritation. Glycine, which is used for chelation is the smallest amino acid. The resultant Ferrous Bis-Glycinate also has low molecular weight which ensures intact absorption. The advantage of Ferrous bisglycinate over other sources of supplemental iron is that its greater bioavailability i.e. 90.9%, into the mucosal cells results in more iron being quickly and safely delivered to target tissues of the body in times of need. This potentially allows for smaller doses of supplemental iron, which can result in fewer gastric complaints and reduced risk of iron overload. Also the solubility of Ferrous Bis-Glycinate is not affected by change in pH (ph 2 – pH 6). This leads to upto 4 times better absorption than other irons. Ferrous bisglycinate chelate was developed to provide a safer product with improved bioavailability.

Folate is a water-soluble vitamin. Folate is critically important for fetal growth and, for this reason, it is required in increased amounts during pregnancy. It is recommended that all women capable of becoming pregnant consume folate in order to reduce the risk of the foetus developing a neural tube defect.

Zinc Bis-Glycinate is a type of zinc supplement. It contains zinc that’s been attached to a chelating agent that bond with metal ions (such as zinc) to create a stable, water-soluble product that can be easily absorbed by the body. Features of zinc deficiency include growth retardation and defects of rapidly dividing tissues such as the skin and the intestinal mucosa.

Methylcobalamin is used for the treatment of vitamin B12 deficiency. Vitamin B12 is very important for the brain and nerves and for the production of red blood cells. The medication is used in people with pernicious anaemia, diabetes and other conditions. It also prevents risk of hyperhomocysteinemia during pregnancy.

Indications

for the prevention and treatment of nutritional deficiency anaemia related to iron and folic acid.

Dosage and method of administration

The dosage is one tablet per day, or as directed by the physician.

Contraindications

It is contraindicated in patients hypersensitive to ferrous bisglycinate, folic acid, zinc or to any other component of this formulation.

Drug Interactions

Notify your doctor if you are on any medication including both over the counter medication or prescription drugs, vitamin supplements and any herbal products before you begin using the medicine. Interactions might lower the effectiveness of the medication, increase chances of side effects occurring or worsen an existing condition.

PREGNANCY

Nutritional supplement doses of vitamins and minerals are generally considered safe during pregnancy.

Warning and Precautions

Do not exceed the recommended dose. The type of anaemia and the underlying cause or causes should be determined before starting therapy with this medication. Since the anaemia may be a result of a systemic disturbance, such as recurrent blood loss, the underlying cause or causes should be corrected, if possible

In general, people with a history of kidney disease, intestinal disease, peptic ulcer disease, enteritis, colitis, pancreatitis, hepatitis, who consume excessive alcohol, who plan to become pregnant, or who have a family history of heart disease should consult a doctor and pharmacist

Side effects/Overdose

SIDE EFFECTS

Adverse reactions with iron therapy may include constipation, diarrhoea, nausea, vomiting, dark stools and abdominal pain. Adverse reactions with iron therapy are usually transient. Gastrointestinal side effects are relatively common and corrective bowel regimens such as increasing dietary fibre or over-the-counter medications might be recommended to balance these side effects. Ferrous bisglycinate shows lesser gastrointestinal side effects as compared to other ferrous salts.

OVERDOSAGE

The clinical course of acute iron over dosage can be variable. Initial symptoms may include abdominal pain, nausea, vomiting, diarrhoea, tarry stools, melena, haematemesis, hypotension, tachycardia, metabolic acidosis, hyperglycaemia, dehydration, drowsiness, pallor, cyanosis, lassitude, seizures, shock and coma.

Except during pregnancy and lactation, folic acid should not be given in therapeutic doses greater than 0.4 mg daily until pernicious anaemia has been ruled out.

Acute zinc toxicity after oral ingestion causes nausea and vomiting, fever, and respiratory distress. Chronic large doses of zinc may depress immune function and cause hypochromic anaemia as a result of copper deficiency.

Pharmacokinetics/Pharmacodynamics

PHARMACODYNAMICS

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