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Page Created On : 23 May 2020 8:23 AM GMT , Page Last Updated On : 12 Jan 2023 10:58 AM GMT

About Cadexomer Iodine Ointment

Cadexomer Iodine Ointment is yellow-brown colored ointment containing cadexomer iodine (50% w/w) equivalent to 0.9% w/w available iodine.

Cadexomer Iodine Ointment is used in external wounds including leg ulcers, pressure ulcers and diabetic ulcers, infected traumatic and surgical wounds. This medicine effectively treats infection by controlling the growth of bacteria, fungi and viruses. It comes in ointment form and should be used for external use only.

Indications of Cadexomer Iodine Ointment

  • Cadexomer Iodine Ointment is indicated for the treatment of exuding wounds such as leg ulcers, pressure ulcers and diabetic ulcers, infected traumatic and surgical wounds.

Dose and Method of Administration


  • Clean the wound with sterile water or saline. Do not dry the wound surface.
  • Apply Cadexomer Iodine Ointment to dry sterile gauze, ensuring an adequate amount to cover the entire wound to a depth of 3 mm.
  • Place secondary dressing over the wound with a gloved finger, smoothen over the dressing and spread the ointment underneathto the shape of the ulcer and to a minimum depth of 3 mm.
  • A single application of Cadexomer Iodine Ointment should not exceed 50 g. The total amount of Cadexomer Iodine Ointment used in one week should not exceed 150 g.
  • The duration of treatment should not exceed 3 months in any single course of treatment


  • Remove secondary dressing
  • Loss of dark-brown coloration confirms need to change dressing (usually 2-3 times a week or daily if wound is discharging heavily).
  • If necessary, soak dressing for a few minutes with sterile water or saline, then remove.
  • Remove Cadexomer Iodine Ointment with a gentle stream of sterile water or saline, using a sterile wet swab if necessary
  • Gently blot excess fluid, leaving wound surface slightly moist, before reapplying Cadexomer Iodine Ointment.
  • The number of applications should be reduced as the exudate diminishes.


  • Patients with known or suspected iodine sensitivity
  • Hashimoto's thyroiditis
  • Patients with history of Graves' disease or
  • Non-toxic nodular goitre
  • Pregnant or lactating womem

Warnings and Precautions

Iodine may be absorbed systematically, when large wounds are treated. Patients with severely impaired renal function or a past history of any thyroid disorder are more susceptible to alterations in thyroid metabolism with chronic Cadexomer Iodine Ointment ointment therapy. In endemic goitre there have been isolated reports of hyperthyroidism associated with exogenous iodine. It has been observed occasionally that an adherent crust can form when Cadexomer Iodine Ointment is not changed at required frequency. Cadexomer Iodine Ointment is not effective in treating dry wounds

Drug Interactions

There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism. Cadexomer Iodine Ointment should not be used concomitantly with taurolidine (since there is a risk of metabolic acidosis) or with mercurial antiseptics, e.g. mercurochrome and thiomersal. Since iodine may be absorbed systemically, the result of tests of thyroid function can be influenced

Download the Product Leaflet, to see the detailed drug interactions

Cadexomer Iodine Side effects/ Overdose

Patients treated with cadexomer iodine ointment may experience a transient smarting or pain within the first hour after application. Minor reddening or swelling around the wound may occur without necessarily being an allergic reaction. Contact allergy and local edema have been reported. There have been no reported over dosages. In case of excessive topical use of Cadexomer Iodine Ointment the treatment should be stopped, the area is washed and symptomatic treatment is initiated.

Download the Product Leafletto see the detailed information on the Cadexomer Iodine Side effects/ Overdose

Pharmacodynamic and Pharmacokinetic Properties

Download the Product Leaflet, to see the details on Pharmacodynamic and Pharmacokinetic Properties of Cadexomer Iodine Ointment

Cadexomer Iodine Journal Update

• Cavity Foot Ulcers in Diabetic Patients: A Comparative Study of Cadexomer Iodine Ointment and Standard Treatment. An Economic Analysis Alongside a Clinical Trial

• Cadexomer iodine provides superior efficacy against bacterial wound biofilms in vitro and in vivo

• The role of povidone and cadexomer iodine in the management of acute and chronic wounds

• The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing

• A Randomized Trial of Cadexomer Iodine in Decubitus Ulcers

• Effect of cadexomer iodine on the microbial load and diversity of chronic non-healing diabetic foot ulcers complicated by biofilm in vivo

• A prospective, non comparative, multicenter study to investigate the effect of cadexomer iodine on bioburden load and other wound characteristics in diabetic foot ulcers

• Efficacy of Cadexomer Iodine in the Treatment of Chronic Ulcers: A Randomized, Multicenter, Controlled Trial

• Cadexomer iodine: A fresh look at an old gem

• Wound Practice and Research