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Myotan

Page Created On : 3 Jun 2020 6:23 AM GMT , Page Last Updated On : 9 Oct 2021 10:34 AM GMT

About

Azilsartan Medoxomil Tablet is an angiotensin II receptor blocker (ARB) used in the therapy of hypertension. It is manufactured and sold in India by Zilarbi,Myotan,Aztric.

Azilsartan inhibits the pressor effects of an angiotensin II infusion in a dose-related manner. Azilsartan blocks the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathway for angiotensin II synthesis

Azilsartan is a highly selective AT1 subtype angiotensin II receptor antagonist. Azilsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. This action relaxes blood vessels and reduces high blood pressure..

Indications

Azilsartan Medoxomil uses in the treatment of hypertension in adult patients, either alone or in combination with other antihypertensive agents.

Dose and Method of Administration

Recommended Dose

The recommended dose in adults is 80 mg taken orally once daily. Consider a starting dose of 40 mg for patients who are treated with high doses of diuretics. If blood pressure is not controlled with Azilsartan alone, additional blood pressure reduction can be achieved by taking Azilsartan with other antihypertensive agents. Azilsartan may be taken with or without food

Contraindications

Do not co-administer Aliskiren with Azilsartan in patients with diabetes.

Warning and Precautions

• Fetal Toxicity (Pregnancy)

• Hypotension in Volume- or Salt-Depleted Patients

• Impaired Renal Function

Drug Interactions

Azilsartan may have drug interactions with the following drugs

• Non-steroidal Anti-Inflammatory Agents, including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors)

• Dual Blockade of the Renin-Angiotensin System (RAS)

• Lithium

Undesirable Side effects/ Overdose

Studies show that treatment with Azilsartan is well-tolerated with an overall incidence of adverse reactions similar to placebo. The most common adverse event leading to discontinuation was hypotension/orthostatic hypotension. Some other side effects may include Gastrointestinal Disorders: nausea, diarrhea, general gisorders and Administration Site Conditions: asthenia, fatigue , musculoskeletal and connective tissue disorders: muscle spasm

Nervous System Disorders: dizziness, dizziness postural, respiratory, thoracic, and mediastinal disorders: cough

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