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uni-k2-7
Uni-K2-7 consists of Vitamin K2 homologue. Vitamin K occurs in two biologically active forms: phylloquinone (vitamin K1) and menaquinones (vitaminK2). Vitamin K1 is produced by green and leafy vegetables, and algae, whereas vitamin K2 is predominantly of microbial origin. It is Manufactured by J.B. Chemicals & Pharmaceuticals Ltd. and is available in two doses- 50 mcg, and 100 mcg.


Vitamin K plays a role in the synthesis of hepatic blood coagulation proteins, in bone health, cardiovascular health, prevention of cancer, and suppression of inflammation, prevention of brain oxidative damage, sphingolipid synthesis, and osteoporosis. ( See Product Leaflet )


Overview
Name of Product: Uni-K2-7
Marketed by : J.B. Chemicals and Pharmaceuticals Ltd
Medicine composition: Vitamin K2 homologue
Prescription vs.OTC: Prescription by Doctor required
Dosage Form: Tablet

The use of Uni- K2-7 has been indicated in Coronary Artery Disease with a high risk of CHD for artery calcification.

Uni K-2-7 is available in two doses; 50 mcg and 100 mcg.

Matrix-Gla- Protein (MGP), Vitamin K, and Cardiovascular Disease (CVD):

  • Among the proteins involved in vascular calcium metabolism, the vitamin K-dependent MGP plays a dominant role.
  • MGP is synthesized primarily by chondrocytes and vascular smooth muscle cells and is found in the cartilage, bone, and vasculature.
  • MGPs, when carboxylated, play a key role in the inhibition of tissue calcification, thus becoming a very critical factor in plaque formation and reversal.
  • Its pivotal importance for vascular health is demonstrated by the fact that there seems to be no effective alternative mechanism for calcification inhibition in the vasculature.
  • Inadequate dietary intake of vitamin K may result in under carboxylation of vascular MGP, leading to enhanced calcification of atherosclerotic lesions and, consequently, an increased risk of coronary heart disease.
  • Generally, It is recommended that individuals on these medications limit Uni K-2-7 consumption to amounts typically found in the average diet (90-120 mcg).
  • Pregnant women on warfarin, anticonvulsants, rifampin, or isoniazid place the newborn at increased risk of Uni K-2-7 deficiency as these medications can interfere with fetal Uni K-2-7 synthesis.
  • Extended use of broad-spectrum antibiotics may decrease Uni-K2-7 synthesis by intestinal bacteria.
  • The use of cephalosporins and salicylates may adversely affect Uni-K2-7 recycling by inhibiting vitamin K epoxide reductase.
  • Furthermore, absorption of Uni-K2-7 may be decreased with the use of drugs such as cholestyramine, colestipol, orlistat, and substances such as mineral oil and the fat substitute, olestra.
  • From a large number of clinical trials using dosages over 40 mg/day, there were no reports of side effects associated with any type of hypercoagulable state.
  • Both animal and clinical studies support the conclusion that Uni-K2-7 has no abnormal hemostatic activity.

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  • A high intake of menaquinones does not increase thrombosis risk.
  • Vitamin K-dependent proteins have a limited number of Gluresidues capable of g-carboxylation per molecule, beyond which there can be no further g-carboxylation or excessive coagulation.

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Protect from light and moisture. Keep away from children.


Each pack consists of three strips with 10 tablets each.

Long-chain menaquinones have more complex disappearance curves with a long half-life. Uni-K2-7 remains detectable even at 72 hrs.

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There is no known toxicity associated with high doses of Uni-K2-7. A point of concern is however the potential interference of K vitamins with OAC treatment: individuals taking anticoagulant medications, such as warfarin (coumarins), should consult their doctor before taking Uni-K2-7.

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