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COVID in Newborns Linked to Necrotizing Enterocolitis Risk: study
COVID in Newborns Linked With Necrotizing Enterocolitis Risk, according to a recent study published in the Annals of Medicine and Surgery
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic on expectant mothers and their babies extends to many aspects of life. Necrotizing enterocolitis (NEC) has been recognized as a life-threatening gastrointestinal inflammatory process in neonates with high morbidity and mortality rates.
A study was conducted to investigate factors associated with NEC in hospitalized neonates whose mothers were SARS-CoV-2-positive and their relationship to mortality. This observational study was conducted from May 2020 to March 2021. All hospitalised neonates after confirming that the mother was SARS-CoV-2-positive were included in this study. The confirmation of positive SARS-CoV-2 was determined according to the reverse transcription-polymerase chain reaction (PCR) assay. The neonatal SARS-CoV-2 test was performed on the first day of birth. NEC was established based on a suggestive clinical presentation and abnormal abdominal radiographs.
Results:
Of the 125 neonates enrolled in this study, there were 5 neonates who developed NEC and only one survived. Significant associated factors with NEC included lower birth weight (p < 0.001), lower gestational age (p < 0.001), positive SARS-CoV-2 PCR results (OR = 15.333; 95% CI = 2.074–113.381, p = 0.007), asphyxia (OR = 13.143; 95% CI = 1.411–122.443, p = 0.024), and mortality (OR = 156.000; 95% CI = 13.157–1849.623; p < 0.001). Mortality was significantly associated with lower gestational age (p = 0.025), cesarean section delivery (p = 0.025), and asphyxia (p = 0.025).
Thus, NEC's significant associated factors in neonates born to SARS-CoV-2-positive mothers included positive SARS-CoV-2 PCR results, asphyxia, lower gestational age, and lower birth weight. In addition to caesarean section delivery, these factors were related to mortality in neonates in such conditions.
Reference:
Observational study on necrotizing enterocolitis in neonates born to SARS-CoV-2-positive mothers by Dina Angelika et al. published in the Annals of Medicine and Surgery.
https://doi.org/10.1016/j.amsu.2022.103711
Keywords:
COVID-19, Newborns, Linked, Necrotizing, Enterocolitis, Risk, Annals of Medicine and Surgery, Dina Angelika, Risa Etik, Naomi Nathania, Kusuma, ward, anic, Setya, MithradI Dewa Gede, Ugrasena, new mothers
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751