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  • 2-dose HPV vaccine...

2-dose HPV vaccine schedule provides sufficient protection for over 2 years: Study

MedhaBy MedhaPublished On 2021-01-14T20:26:21+05:30  |  Updated On 2021-01-15T12:24:18+05:30
2-dose HPV vaccine schedule provides sufficient protection for over 2 years: Study

Israel: After the last dose of a 2-dose 9vHPV vaccine regimen in boys and girls, antibody response persists through 2 to 2.5 years, finds a recent study in the journal Pediatrics.The findings suggests that antibody response generated by administering 2 doses administered 6 to 12 months apart may be sufficient to induce high-level protective efficacy at least for 2 years after...

Israel: After the last dose of a 2-dose 9vHPV vaccine regimen in boys and girls, antibody response persists through 2 to 2.5 years, finds a recent study in the journal Pediatrics.

The findings suggests that antibody response generated by administering 2 doses administered 6 to 12 months apart may be sufficient to induce high-level protective efficacy at least for 2 years after the second dose.

A recent international, randomized, open-label trial found human papillomavirus (HPV) antibody responses to the 9-valent human papillomavirus (9vHPV) vaccine among girls and boys (aged 9–14 years) receiving 2-dose regimens (months 0, 6 or 0, 12) to be non inferior to a 3-dose regimen (months 0, 2, 6) in young women (aged 16–26 years) 4 weeks after last vaccination. Jacob Bornstein, Galilee Medical Center and Azrieli Faculty of Medicine, Bar-Ilan University, Nahariya, Israel, and colleagues assessed response durability through month 36.

Girls received 2 (months 0 and 6 [0, 6]: n = 301; months 0 and 12 [0, 12]: n = 151) or 2 doses (months 0,2, and 6 [0, 2, 6]: n = 301). boys received 2 doses ([0, 6]: n = 301; [0, 12]: n = 150); and young women received 3 doses ([0, 2, 6]: n = 314) of 9vHPV vaccine. Using competitive Luminex immunoassay (cLIA) and immunoglobulin G-Luminex immunoassay (IgG-LIA) through month 36, the researchers assessed anti-HPV geometric mean titers (GMTs). 

Key findings of the study include:

  • Anti-HPV GMTs were highest 1 month after the last 9vHPV vaccine regimen dose, decreased sharply during the subsequent 12 months, and then decreased more slowly. GMTs 2 to 2.5 years after the last regimen dose in girls and boys given 2 doses were generally similar to or greater than GMTs in young women given 3 doses.
  • Across HPV types, most boys and girls who received 2 doses (cLIA: 81%–100%; IgG-LIA: 91%–100%) and young women who received 3 doses (cLIA: 78%–98%; IgG-LIA: 91%–100%) remained seropositive 2 to 2.5 years after the last regimen dose.

"In girls and boys, antibody responses generated by 2 doses administered 6 to 12 months apart may be sufficient to induce high-level protective efficacy through at least 2 years after the second dose," wrote the authors.

The study titled, "Three-Year Follow-up of 2-Dose Versus 3-Dose HPV Vaccine," is published in the journal Pediatrics.

DOI: https://pediatrics.aappublications.org/content/147/1/e20194035



journal Pediatrics Human papillomavirus HPV vaccine antibody response 
Source : journal Pediatrics
Medha
Medha

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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