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  • Acetaminophen with...

Acetaminophen with ibuprofen therapy effective in febrile children: Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-01-31T20:30:08+05:30  |  Updated On 31 Jan 2025 8:30 PM IST
Acetaminophen with ibuprofen therapy effective in febrile children: Study
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A new study published in the journal of Pediatrics showed that when treating children with fever, combination therapy may be more effective than monotherapy. Since fever is a common early clinical sign of acute infections, it has long been a symptom of great worry to parents and clinicians. Parents frequently experience worry and anxiety when their child has refractory fever, which is characterized by a poor response to an antipyretic medication or a fever return prior to the next pharmacological dose.

Despite worries about possible medication toxicity and negative interactions, children with refractory fever have been treated in practice using a regimen of alternating acetaminophen and ibuprofen at various doses and intervals. Also, the safety of alternating antipyretic treatment has not yet been shown, and the risk of improper and excessive administration is increased by the probability that parents may not comprehend dosage recommendations. It is unclear if the effects and safety of acetaminophen and ibuprofen as single or dual (alternating or combination) therapy are comparable. Thus, using a systematic review and network meta-analysis, Juan and his colleagues carried out this study to evaluate the relative effectiveness of acetaminophen, ibuprofen alone, alternating, or in combination.

From the beginning until September 20, 2023, Embase, Medline and CENTRAL were examined for this investigation. Randomized studies comparing the use of acetaminophen, ibuprofen, both alternating and both combined, to treat fever in children were carefully validated. The study used the random-effects model for both pairwise and network meta-analysis.

There were 31 trials (5009 children) in this research. In terms of the percentage of afebrile children in the 4th hour, this study discovered that ibuprofen at a high dose may be equivalent to acetaminophen (OR, 0.98; CI, 0.63–1.59), while combined and alternating therapy (OR, 0.20; CI, 0.06–0.63) may be preferable. At the 6th hour, these outcomes were comparable. Regarding adverse events, there were no differences between ibuprofen (low or high dosage), alternating, or coupled with acetaminophen.

When it came to managing fever in children, dual therapy could be better than solo ones. And in the case of treating afebrile kids between four and six hours, acetaminophen might not be as effective as alternate or combination therapy. Acetaminophen performed similarly to ibuprofen at 6 hours but worse than ibuprofen alone at 4 hours.

Reference:

De la Cruz-Mena, J. E., Veroniki, A.-A., Acosta-Reyes, J., Estupiñán-Bohorquez, A., Ibarra, J. A., Pana, M. C., Sierra, J. M., & Florez, I. D. (2024). Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis. In Pediatrics (Vol. 154, Issue 4). American Academy of Pediatrics (AAP). https://doi.org/10.1542/peds.2023-065390

Pediatrics journalAcetaminophenIbuprofen
Source : Pediatrics
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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