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  • Biodegradable tracheal...

Biodegradable tracheal stents make breathing easier for kids with tracheal stenosis

Hina ZahidWritten by Hina Zahid Published On 2021-01-17T18:30:02+05:30  |  Updated On 17 Jan 2021 1:00 PM GMT
Biodegradable tracheal stents make breathing easier for kids with tracheal stenosis
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Pediatric laryngotracheal stenosis (LTS), a narrowing of the airway in children, is a complex medical condition. While it can be something a child is born with or caused by injury, the condition can result in a life-threatening emergency if untreated.Treatment, however, is challenging. Depending on the severity, doctors will use a combination of endoscopic techniques, surgical...

Pediatric laryngotracheal stenosis (LTS), a narrowing of the airway in children, is a complex medical condition. While it can be something a child is born with or caused by injury, the condition can result in a life-threatening emergency if untreated.

Treatment, however, is challenging. Depending on the severity, doctors will use a combination of endoscopic techniques, surgical repair, tracheostomy, or deployment of stents to hold the airway open and enable breathing.

While stents are great at holding the airway open and simultaneously allowing the trachea to continue growing, they can move around, or cause damage when they're eventually removed.

New research published in Communications Biology and led by the University of Pittsburgh is poised to drastically improve the use of stents, demonstrating for the first time the successful use of a completely biodegradable magnesium-alloy tracheal stent that avoids some of these risks.

"Using commercial non-biodegradable metal or silicone based tracheal stents has a risk of severe complications and doesn't achieve optimal clinical outcomes, even in adults," said Prashant N. Kumta, Edward R. Weidlein Chair Professor of bioengineering at the Swanson School of Engineering. "Using advanced biomaterials could offer a less invasive, and more successful, treatment option."

In the study, the balloon-expandable ultra-high ductility (UHD) biodegradable magnesium stent was shown to perform better than current metallic non-biodegradable stents in use in both in lab testing and in rabbit models. The stent was shown to keep the airway open over time and have low degradation rates, displaying normal healing and no adverse problems.

"Our results are very promising for the use of this novel biodegradable, high ductility metal stent, particularly for pediatric patients," said Kumta, who also holds appointments in Chemical and Petroleum Engineering, Mechanical Engineering and Materials Science, and the McGowan Institute of Regenerative Medicine. "We hope this new approach leads to new and improved treatments for patients with this complex condition as well as other tracheal obstruction conditions including tracheal cancer."

https://www.nature.com/articles/s42003-020-01400-7


breathingtracheal stentpediatric laryngotracheal stenosisendoscopic techniquescommunications biology
Source : Communications Biology
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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