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COVID-19 vaccination safe in patients with history of multisystem inflammatory syndrome in children: JAMA

Written By : Dr. Kamal Kant Kohli Published On 2023-01-10T09:30:43+05:30  |  Updated On 14 Feb 2024 1:57 AM IST
COVID-19 vaccination safe in patients with history of multisystem inflammatory syndrome in children: JAMA
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USA: A recent study in JAMA Network Open showed that history of multisystem inflammatory syndrome in children (MIS-C) is not associated increased risk of serious adverse reactions following COVID-19 vaccination in children and adolescents. there were no reports of serious complications including myocarditis or MIS-C reoccurrence

About half of participants experienced mild and typical reactions, including arm soreness and fatigue.

The multicenter, observational study, the largest of its kind to examine COVID vaccination in this group, helps resolve a lingering question about whether the COVID vaccine can increase the risk of health problems in young people who have had MIS-C, a rare and potentially fatal immunological reaction that can occur following infection with SARS-CoV-2, the virus that causes COVID-19.

MIS-C is a poorly understood condition that affects 1 in about 3,000 to 4,000 children and adolescents who had COVID-19, according to the Centers for Disease Control and Prevention (CDC). It occurs a few weeks after COVID infection and can lead to organ failure. Symptoms can range from stomach pain, fever, and rash to inflammation of the heart muscle, a serious condition called myocarditis. The exact causes of MIS-C are unknown, but medications can be given to decrease the inflammation that can damage organs.

Some families and healthcare professionals have questioned whether COVID vaccines could lead to more serious adverse reactions in those with a history of MIS-C, including a recurrence of the disease, but data on this topic were lacking.

The cross-sectional study included 22 medical centers (21 in the United States and 1 in Canada) participating in the NHLBI’s Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children (MUSIC) study. It enrolled 385 patients aged 5 years or older with prior MIS-C who were eligible for COVID-19 vaccination. Of this group,185 (48.1%) received at least one vaccine dose. The median age was 12.2 years and 73.5% were male. The participants were racially diverse-24.3% were Black, 31.9% were Hispanic, and 28.6% were white. The median length of time from their MIS-C diagnosis to their first vaccine dose was 9 months.

Of those who received a COVID vaccination following MIS-C, mild adverse reactions-mostly arm soreness and fatigue – occurred in 49% of them, similar to the general population. There were no reports of serious complications, including myocarditis or recurrence of MIS-C, the researchers said.

“We are very reassured by the results and this safety data should be comforting to families and healthcare professionals when considering and recommending vaccination,” said study co-leader Matthew D. Elias, M.D., a pediatric cardiologist at Children’s Hospital of Philadelphia and clinical assistant professor of pediatrics at the University of Pennsylvania, Philadelphia. Audrey Dionne, M.D., a pediatric cardiologist at Boston Children’s Hospital and assistant professor of pediatrics at Harvard Medical School, Boston, also served as the study’s co-leader. The researchers have routinely treated children with MIS-C throughout the pandemic.

Dionne added that the findings provide support for the CDC’s recommendation that patients with a history of MIS-C receive a COVID vaccine at least 90 days after diagnosis and that it is safe to do so.

“In light of the acute and long-term consequences of COVID-19 it is vital to continue the development, testing, and deployment of preventive as well as therapeutic agents in at-risk groups as well as the general population,” said Gary H. Gibbons, M.D., director of the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.

To date, more than 9,000 patients have been diagnosed with MIS-C in the United States, and 74 have died, according to data from the CDC (https://covid.cdc.gov/covid-data-tracker/#mis-national-surveillance). However, the disease appears to be on the decline, according to studies by others.

“A big part of that decline is that COVID vaccination has been protective against this rare condition in those who have received it,” Dionne said.

While many patients with MIS-C make a full clinical recovery, some studies suggest chronic symptoms linger after MIS-C, which is why long-term outcome studies will be beneficial, the researchers said. The MUSIC study is part of an NIH collaborative research effort called CARING for Children with COVID, which aims to better understand how COVID affects children, who account for roughly 13% of the total cases in the United States.

Reference:

Elias MD, Truong DT, Oster ME, et al. Examination of Adverse Reactions After COVID-19 Vaccination Among Patients With a History of Multisystem Inflammatory Syndrome in Children. JAMA Netw Open. 2023;6(1):e2248987. doi:10.1001/jamanetworkopen.2022.48987

JAMA Network OpenCOVID-19COVID vaccineMIS-Cmultisystem inflammatory syndromemyocarditisSARS-CoV-2heart muscle
Source : JAMA Network Open
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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