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  • Daily steroids improve...

Daily steroids improve motor and pulmonary function in kids with Duchenne muscular dystrophy: JAMA

Written By : Dr. Kamal Kant Kohli Published On 2022-05-06T20:30:41+05:30  |  Updated On 7 May 2022 12:44 PM IST
Daily steroids improve motor and pulmonary function in kids with Duchenne muscular dystrophy: JAMA
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New research published in JAMA recommends daily steroid doses for children with Duchenne muscular dystrophy (DMD), marking a significant change in how the disease is treated. University of Rochester Medical Center (URMC) neurologist Robert Griggs, M.D., and Michela Guglieri, M.D., with Newcastle University in the U.K., led the study, which was conducted by a global team of researchers dedicated to improving care for this fatal disease.

"Corticosteroids are likely to remain the main treatment for DMD for the foreseeable future and worldwide so it is critical that we establish a standard of care that is backed by scientific evidence," said Griggs. "This study shows that health concerns over the daily use of corticosteroids are overstated and that there is a clear benefit in terms of improved motor and pulmonary functions. These findings clearly support the daily regimen over an intermittent one as an initial treatment for boys with DMD."

DMD is a condition found almost exclusively in boys and characterized by muscle weakness, which appear at age 3-4 and progresses rapidly leading to significant disability. The symptoms eventually spread to the heart and muscles responsible for breathing, and the disease is often fatal by the time the boy reaches his late teens. An estimated 28,000 people in the U.S. suffer from the disease.

While corticosteroids prednisone and deflazacort are known to improve muscle strength and function in patients with DMD and have been a frontline treatment for years, there is currently no universally accepted standard for steroid use in DMD. A global survey of physicians who treat DMD found 29 different regimens, with the most common being ten days on and ten days off. This intermittent dosing regimen was put in place in an effort to limit the potential side effects associated with prolonged steroid use in children, such as weight gain, stunted growth, and loss of bone density.

The Finding the Optimum Regimen of Corticosteroids for DMD (FOR-DMD) study was launched in 2013 to compare daily and intermittent steroid use and establish, from clinical benefit and safety perspective, the most beneficial regimen for DMD patients. Griggs and Kate Bushby, M.D., with Newcastle University initiated the phase 3 clinical trial conducted through the Muscle Study Group, an international network of muscular dystrophy researchers that Griggs helped create in 1997 to advance clinical research in neuromuscular disorders, including DMD.

The new study recruited 196 boys with DMD at 32 research sites across North American and Europe and followed them for three years. Participants were assigned to three groups consisting of daily regimens of prednisone or deflazacort, or intermittent prednisone, and followed for three years. The researchers found that the daily regimens of both drugs significantly slowed disease progression as measured by strength testing and muscle function, as compared to the intermittent group. While the daily regimen increased side effects overall, there were minimal serious side effects.

For more details, visit here:

https://www.urmc.rochester.edu/news/story/daily-steroids-safe-and-slow-progression-of-duchenne-muscular-dystrophy

JAMADuchenne muscular dystrophyDMDmuscular dystrophychildrenCorticosteroidsdrug researchsteroidsUniversity of Rochester Medical CenterURMC
Source : JAMA
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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