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  • Early treatment of...

Early treatment of Chronic Hepatitis C in Children prevents Complications: Study

Dr. Nandita MohanBy Dr. Nandita MohanPublished On 2021-03-09T06:45:01+05:30  |  Updated On 2021-03-09T06:45:07+05:30
Early treatment of Chronic Hepatitis C in Children prevents Complications: Study

According to recent research, investigators have observed that delaying treatment until age 18 years results in an increased lifetime risk of late-stage liver complications, as published in the Journal of Pediatrics. Emma Greenaway and colleagues from the Division of Gastroenterology Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada...

According to recent research, investigators have observed that delaying treatment until age 18 years results in an increased lifetime risk of late-stage liver complications, as published in the Journal of Pediatrics.

Emma Greenaway and colleagues from the Division of Gastroenterology Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada carried out this study to evaluate the cost-effectiveness of treating young children with chronic hepatitis C virus (HCV) with new direct-acting antivirals.

A state-transition model of chronic HCV was developed to conduct a cost-effectiveness analysis comparing treatment at age 6 years vs delaying treatment until age 18 years. Model inputs were derived from recently conducted systematic reviews, published literature, and government statistics.

Medical care costs were obtained from linked population level laboratory and administrative data (Ontario, Canada). Outcomes are expressed in expected quality-adjusted life-years and costs (CAD$). Analysis included a base-case to estimate the expected value and one-way and probabilistic sensitivity analyses to evaluate the impact of uncertainty of the model inputs.

The results showed that -

a. After 20 years, treating 10 000 children early would prevent 330 cases of cirrhosis, 18 cases of hepatocellular carcinoma, and 48 liver-related deaths.

b. The incremental cost-effectiveness ratio of early treatment compared to delayed treatment was approximately $12 690/quality-adjusted life-years gained and considered cost-effective.

c. Model results were robust to variation in fibrosis progression rates, disease state-based costs, treatment costs, and utilities.

Therefore, the authors concluded that "Delaying treatment until age 18 years results in an increased lifetime risk of late-stage liver complications. Early treatment in children is cost effective. This work supports clinical and health policies that broaden HCV treatment access to young children."

Hence, it was further added that treatment of Chronic Hepatitis C in Young Children Reduces Adverse Outcomes and Is Cost-Effective Compared with Deferring Treatment to Adulthood.


chronic hepatitis c young children Adverse Outcomes cost-effectiveness the journal of pediatrics 
Source : Journal of Pediatrics
Dr. Nandita Mohan
Dr. Nandita Mohan

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped.

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