Exposure to High grass pollens may lower lung function in children with food allergies
Increasing short-term exposure to ambient grass pollen was significantly tied with reversible obstructive lung function deficits in children with allergic disease, according to a recent study published in the Journal of Allergy and Clinical Immunology: In Practice.
Grass pollen exposure is a risk factor for childhood asthma hospital attendances. However, its short-term influence on lung function especially among those with other allergic conditions has been less well-studied.
A study was conducted to investigate this association in a population-based sample of children. Within the HealthNuts cohort, 641 children performed spirometry during the grass pollen season. Grass pollen concentration was considered on the day of testing (lag 0), up to three days before (lag 1-lag 3) and cumulatively (lag 0-3). We used linear regression to assess the relevant associations and examined potential interactions with current asthma, hay fever or eczema, and food allergy.
The results of the study are:
- Associations were observed only in children with allergic disease (p-value for interaction ≤ 0.1)
- In children with food allergy, grass pollen concentration was associated with lower ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) and lower mid-forced expiratory flows (FEF25-75%) at all lags (e.g. at lag-2, FEV1/FVC z-score = -0.50 [95% CI: -0.80, -0.20] and FEF25-75% z-score = -0.40 [-0.60, -0.04] per 20 grains/m3 pollen increase), and increased bronchodilator responsiveness (BDR) at lag-2 and lag-3 (e.g. at lag-2, BDR = (31 [-0.005, 62] ml).
- In children with current asthma, increasing grass pollen concentration was associated with lower FEF25-75% and increased BDR, while children with current hay fever or eczema had increased BDR only.
Thus, a proactive approach needs to be enforced to manage susceptible children, especially those with food allergies, before high grass pollen days.
Reference:
Children with food allergies are at risk of lower lung function on high pollen days by N. Sabrina Idrose, et al. published in the Journal of Allergy and Clinical Immunology: In Practice.
DOI: https://doi.org/10.1016/j.jaip.2022.03.022
Keywords:
High, grass, pollen, association, lower, lung function, children, food allergies, Journal of Allergy and Clinical Immunology: In Practice, N. Sabrina Idrose, Don Vicendese, Rachel L. Peters, Bircan Erbas, Caroline J. Lodge, Shyamali C. Dharmage, Atopy, eczema, food allergy, grass pollen, lung function, paediatrics
