- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Fluoroquinolones tied with Higher Pediatric C Difficile Hospitalization Rate: Study
New research published in the Frontiers in Pediatrics on pediatric patients with clostridium difficile infections (CDI) could ultimately result in future studies identifying risk factors within the pediatric population.
Clostridioides difficile, formerly known as Clostridium difficile, is a Gram-positive, spore-forming, anaerobic bacillus, which can exist both in toxigenic and non-toxigenic form. It is transmitted through the fecal–oral route or by direct contact. C. difficile is responsible for healthcare-associated diarrhea, but it is more common in adult with high mortality in elderly patients. Instead, C. difficile colonization is more frequent in the pediatric population, where most are asymptomatic. One major explanation is the absence of toxin-binding receptors in the immature intestinal mucosa of children In recent years, the colonization rate has also increased in the pediatric population, even in the community setting. While there are numerous studies regarding Clostridioides difficile infection (CDI) in adults, literature on the pediatric population is scarce.
Therefore, researchers performed a 5-year retrospective study between January 2014 and December 2018 in two referral centers in Rome, Italy. There were 359 patients tested for CDI who were enrolled: 87 resulted in positive and 272 in negative.
The results of the study are:
- CDI children had a higher number of previous-day hospital admissions (p = 0.024), hospitalizations (p = 0.001), and total hospital admissions (p = 0.008).
- Chronic comorbidities were more frequent in the CDI group (66.7% vs. 33.3%). Previous use of proton pump inhibitors and antibiotics was associated with CDI (p < 0.001).
- Among the antibiotics, only fluoroquinolones were significantly associated with CDI. Also, CDI children were more frequently exposed to antibiotics during the episode of hospitalization when children were tested.
Thus, the researchers concluded that this study provides an updated clinical and epidemiological analysis of children with CDI compared with a control group of children who tested negative. Further prospective studies could better define risk factors and preventive methods.
Reference:
Clostridioides difficile Infection in Children: A 5-Year Multicenter Retrospective Study by Danilo Buonsenso et al. published in the Frontiers in Pediatrics.
https://doi.org/10.3389/fped.2022.783098
Keywords:
Danilo Buonsenso, Rosalia Graffeo4, Davide Pata, Piero Valentini, Carla Palumbo, Luca Masucci, Antonio Ruggiero, Giorgio Attinà , Manuela Onori, Laura Lancella, Barbara Lucignano, Martina Di Giuseppe, Paola Bernaschi8 and Laura Cursi, Clostridioides, difficile, Infection, Children, 5-Year Multicenter, Retrospective, Study, Frontiers in Pediatrics.
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751