- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
High Dose of Vitamin D Benefits Children with Coeliac Disease: Study
It is known now that Celiac disease(CD) is the most common genetically predetermined condition in humans with a growing prevalence worldwide. It causes deficiency of various micronutrients including vitamin D. In a study, researchers have found that a high dose of oral vitamin D for 12 weeks along with a gluten-free diet (GFD) has a better impact on mucosal recovery in children with Coeliac disease. The study findings were published in the Pediatrics and International Child Health on May 14, 2021.
Vitamin and mineral deficiencies have been noted to be common in a population of children with recently diagnosed celiac disease. Based on recent findings, experts recommend screening for vitamin D status in children at the time of initial diagnosis for celiac disease as osteoporosis and hyperparathyroidism in CD is linked to vitamin D deficiency. Researchers of Kalawati Saran Children's Hospital and Lady Hardinge Medical College, New Delhi conducted a study to further evaluate the prevalence of vitamin D deficiency in children newly diagnosed with CD and the role of oral high-dose vitamin D in its treatment.
In this cohort study, they included a total of 120 children and compared 60 CD diagnosed children aged 0–18 years with 60 healthy children. They evaluated the calcium intake, sun exposure and biochemical and radiological parameters related to vitamin D deficiency. CD Children with serum 25(OH)D (<20 ng/ml) were given oral vitamin D (60,000 IU/week) and calcium (500 mg/day) for 12 weeks, along with a gluten-free diet (GFD); they were re-evaluated within a week of completion. The major outcome assessed was the serum 25(OH)D level. The researchers also assessed serum calcium, phosphorus, alkaline phosphatase, parathormone and clinical and/or radiological rickets.
Key findings of the study were:
- Upon analysis, the researchers found that the prevalence of vitamin D deficiency (25(OH)D <20 ng/ml) was significantly greater in the children with CD (n=38, 63.3%) than in the healthy children (n=27, 45.0%).
- Upon treatment, they observed that all 38 CD children with vitamin D deficiency showed a significant rise in 25(OH)D levels along with normalisation of other biochemical abnormalities.
- They also observed that two children had 25(OH)D levels >100 ng/ml with no other feature suggestive of vitamin D toxicity.
The authors concluded, "Vitamin D deficiency is more prevalent in children with CD. Administration of oral high-dose vitamin D for 12 weeks along with a GFD leads to a robust response, indicating rapid mucosal recovery. The vitamin D dosage recommended for malabsorption states may be excessive in CD."
For further information:
DOI: https://doi.org/10.1080/20469047.2021.1996089
Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751