High pretreatment LDH raises mortality risk in children with adenoviral pneumonia

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-01-25T20:00:43+05:30 | Updated On 25 Jan 2023 8:00 PM IST

China: A new research from China found that high pretreatment lactate dehydrogenase (LDH) may increase the risk of mortality in children with adenoviral pneumonia (ADVP) as it is associated with disease severity, development of postinfectious bronchiolitis obliterans (PIBO). The study results were published in the journal Frontiers in Pediatrics.

Adenoviruses are ubiquitous DNA viruses that cause a wide variety of illnesses in children and adults, including pneumonia. Severe adenoviral pneumonia (ADVP) in children has a poor prognosis and a high risk of mortality. Min Zou et al from Guangxi International Zhuang Medical Hospital, China conducted a meta-analysis to evaluate the association between pretreatment lactate dehydrogenase (LDH) and severity, postinfectious bronchiolitis obliterans (PIBO), and mortality in children with ADVP.

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Researchers included relevant observational studies by searching databases like PubMed, Embase, Web of Science, Wanfang, and CNKI databases from inception to August 3, 2022. The results were pooled using a random effect model by incorporating the potential between-study heterogeneity.

Key findings:

Nearly 23 studies with 4481 children having ADVP were included in this meta-analysis.
Children with severe ADVP had a significantly higher level of pretreatment LDH as compared to those with non-severe ADVP.
The pretreatment LDH was significantly higher in children who developed PIBO as compared to those who did not as per the pooled results.
Higher pretreatment LDH of > 500 IU/L was found to be a risk factor for increased mortality during hospitalization.
Sensitivity analyses showed consistent results by excluding one dataset at a time.

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Thus, in children with ADVP, high pretreatment LDH may be linked with the severity of the disease, the development of PIBO, and an increased mortality risk.

Further reading: Lactate dehydrogenase and the severity of adenoviral pneumonia in children: a meta-analysis. doi: 10.3389/fped.2022.1059728

Frontiers in PediatricsPediatric Infectious DiseasesMin Zouadenoviral pneumonia

Source : Frontiers in Pediatrics

Dr.Niharika Harsha B

BDS, MDS

Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751