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  • Hybrid closed loop...

Hybrid closed loop therapy may improve quality of life in Type I Diabetes, finds study

dr anushaBy dr anushaPublished On 2021-11-11T09:00:31+05:30  |  Updated On 2021-11-11T09:00:57+05:30
Hybrid closed loop therapy may improve quality of life in Type I Diabetes, finds study

With significant innovations in the management of type 1 diabetes (T1D), automation in closed-loop systems offers the potential to reduce diabetes burden and improve glucose profile. The hybrid closed-loop (HCL) system uses a control algorithm that delivers insulin based on CGM(Continuous Glucose Monitor) glucose measures. Recent randomized clinical trial (RCT) in adults demonstrated...

With significant innovations in the management of type 1 diabetes (T1D), automation in closed-loop systems offers the potential to reduce diabetes burden and improve glucose profile.

The hybrid closed-loop (HCL) system uses a control algorithm that delivers insulin based on CGM(Continuous Glucose Monitor) glucose measures. Recent randomized clinical trial (RCT) in adults demonstrated improvement in all glycemic metrics with HCL compared with standard therapy with multiple daily insulin injections (MDI) or continuous subcutaneous insulin infusion (CSII), no such trails exists among adolescents.

Researchers from Australia conducted a study to evaluate the effectiveness of Hybrid closed-loop system in young adults and adolescents with type I diabetes.

In this randomized clinical trial participants aged 12 to 25 years were recruited at 5 tertiary pediatric diabetic centers in Australia. Participants were included if they had a history of type I DM for one year, with a fasting C-peptide level of less than 0.30 ng/mL and HbA1c of less than 10.5% on standard therapy. Participants were excluded if they had used any noninsulin glucose lowering agent or corticosteroid within the preceding 3months;or any other chronic illness.

A total of 135 patients were included, with 68 randomized to the control group and 67 to the HCL group. Participants in both the groups were followed up at 4 weeks, 13 weeks and 26 weeks after randomization. The primary outcome was the percentage of time in range

(TIR) within a glucose range of 70 to 180mg/dL, measured by 3-week masked CGM collected

at the end of the study in both groups. Secondary outcomes included CGM metrics for

hypoglycemia, hyperglycemia, and glycemic variability and psychosocial measures.

Key findings of the study are:

-In this study ,patients had a mean (SD) diabetes duration of 7.7 (4.3) years and mean hemoglobin A1c of 64 (11) mmol/mol.

-A total of 110 participants (81%) receiving continuous subcutaneous insulin infusion and 72 (53%) receiving CGM.

-Upon analysis it was found that there was a significant difference in TIR between two groups with a P value of 0.002, the HCL group attaining better control.

-The recommended target of TIR above 70% was met in 31% of participants receiving

HCL and 15% of participants receiving standard therapy. Likewise, the glycemic target of

HbA1c less than 7% was achieved in 16 participants (25.4%) receiving HCL and 11 participants (19.0%) receiving standard therapy.

-Hybrid closed-loop therapy also reduced the time that patients spent in a hypoglycemic (<70mg/dL) range and improved glycemic variability.

-Improved diabetic-specific quality of life and treatment satisfaction was observed in the HCL group as compared to conventional therapy.

Authors conclude-"The HCL system represents an important step in the pursuit of technological advancements toward a fully automated closed-loop system as it showed improved glycemic control and quality of life compared with conventional therapy in children and adolescents with type 1 diabetes."

Source:JAMA pediatrics

type 1 diabetes hybrid closed-loop insulin therapy continuous subcutaneous insulin infusion JAMA Pediatrics 
Source : JAMA pediatrics
dr anusha
dr anusha

    Dr Anusha S completed her M.B.B.S from Dr. P.S.I.M.S ,Vijayawada and M.D. Pediatrics from prestigious Manipal University. Currently working as senior resident in Department of Pediatrics , Mallreddy Medical College for Women, Hyderabad. She is also actively involved in various research activities of department.

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