Medical Dialogues
  • Dermatology
Sign in Signup
This site is intended for healthcare professionals only
Sign in Signup
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
Medical Dialogues
  • Medical News
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Medical Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
  • MDTV
      • Anesthesia
      • CTVS
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • Diet and nutrition
      • ENT
      • Gastroenterology
      • Health Dialogues
      • Health News today
      • Health Shorts
      • Health Updates
      • Health video of the day
      • Laboratory Medicine
      • Latest Videos
      • Latest Webinars
      • MD shorts
      • Medical News Today
      • Medical Updates
      • Medical Video of the day
      • Medicine
      • Nephrology
      • Neurology and Neurosurgery
      • Obstetrics and Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics & Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Top Videos
      • Urology
This site is intended for healthcare professionals only
Sign InRegister
Medical Dialogues
Sign inRegister
  • Home
  • Medical news
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Medical Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
  • Case of the Day
  • Editorial
  • Home
  • Pediatrics and Neonatology
  • Pediatrics and Neonatology News
  • Moderna vaccine...

Moderna vaccine effective against COVID-19 in adolescents: NEJM study

dr anushaBy dr anushaPublished On 2021-08-21T09:00:38+05:30  |  Updated On 2021-08-21T09:01:03+05:30
Moderna vaccine effective against COVID-19 in adolescents: NEJM study

Although Covid-19 illness is generally milder in children than adults, children can have severe disease leading to hospitalization and there is growing concern about MISC. Child continue to be disproportionately affected by the pandemic due to disease per se and also the psychological effects following school closure. The mRNA-1273 vaccine( moderna) has received emergency use authorization...

Although Covid-19 illness is generally milder in children than adults, children can have severe disease leading to hospitalization and there is growing concern about MISC. Child continue to be disproportionately affected by the pandemic due to disease per se and also the psychological effects following school closure.

The mRNA-1273 vaccine( moderna) has received emergency use authorization from the Food and Drug Administration (FDA) in December 2020 for use in adults 18 years of age or older. Kashif et al conducted a phase 2–3 COVE(COVID efficacy) trial to evaluate the use of mRNA-1273 in adolescents between the ages of 12 and 17 years of age and found that there were no serious adverse events following vaccination.

A total of 3732 participants were randomly assigned in a 2:1 ratio to receive two injections of either mRNA1273 vaccine (each injection containing 100 μg, for a total dose of 200 μg;2489 participants) or placebo (saline,1243 participants), 28 days apart. Male and female adolescents between age 12 to 17 years with good general health were enrolled. Primary end point was to assess the safety and reactogenecity of vaccine. Secondary end point was about immunogenicity by comparing antibody titers in phase 2 trial with those of young adult recipients in the efficacy phase 3 trial.

During the study period more than 98% participants received second dose injection. Recipients of mRNA-1273 vaccine were noticed to have more local reactions(94.2% after first injection,93.4% after second injection) than the placebo group(36.8% after first injection,32.6% after second injection). Injection site pain was the most common local side effect in both the groups. Systemic adverse reactions were reported in 68.5% of mRNA-1273 vaccine recipients most common being fatigue, headache and myalgias and were less commonly reported in placebo participants. Solicited local or systemic reactions generally persisted for a mean of approximately 4 days.

Unsolicited adverse events up to 28 days after any injection were more frequent in the mRNA1273 group (20.5%) than in the placebo group (15.9%) ; the most common events in the mRNA-1273 group were injection-site lymphadenopathy and headache. Only one patient had grade 2 anaphylaxis on day 21 after second vaccination dose but was attributed to tree nut allergy and possibility of vaccine adverse event was ruled out.

The mean neutralizing antibody titers in adolescents of phase 2 trial was similar to the titers of adults of phase 3 trial thus proving non-inferiority of immunological response. The vaccine efficacy of mRNA-1273 was 39.2% for asymptomatic infection with an onset of 14 days after the second injection (per-protocol population) and 59.5% with an onset of 14 days after the first injection.

As children and adolescents are asymptomatic carriers, widespread vaccination of this group could further reduce community transmission and enhance herd immunity. The availability of effective vaccines in adolescents is also important to further reduce the reservoir of SARS-CoV-2.

Authors conclude-"it appears that the mRNA-1273 vaccine safely induced levels of antiviral antibodies that should be protective against SARS-CoV-2 infection" .

Source:NEJM

moderna vaccine COVID-19 Vaccination in children efficacy of mRNA-1273 vaccine NEJM 
Source : New england Journal of Medicine
dr anusha
dr anusha

    Dr Anusha S completed her M.B.B.S from Dr. P.S.I.M.S ,Vijayawada and M.D. Pediatrics from prestigious Manipal University. Currently working as senior resident in Department of Pediatrics , Mallreddy Medical College for Women, Hyderabad. She is also actively involved in various research activities of department.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Review: Efficacy of Antiviral Agents Against  Omicron Subvariant BA.2

    Review: Efficacy of Antiviral Agents Against Omicron Subvariant BA.2

    Choice of Antibiotics in Common Infections: Doxycycline or Azithromycin?

    Choice of Antibiotics in Common Infections: Doxycycline or Azithromycin?

    Role of acyclovir in Management of chickenpox: Analyzing the importance of starting early

    Role of acyclovir in Management of chickenpox: Analyzing the importance of starting early

    Parkinsonism and the place of Amantadine - Review Analysis

    Parkinsonism and the place of Amantadine - Review Analysis

    When to Introduce time tested drug Amlodipine to manage Hypertension?

    When to Introduce time tested drug Amlodipine to manage Hypertension?

    View All

    Journal Club Today

    Quitting Smoking After Lung Cancer Diagnosis Worth Doing

    Quitting Smoking After Lung Cancer Diagnosis Worth Doing

    View All

    Health News Today

    Health Bulletin 17/May/2022

    Health Bulletin 17/May/2022

    View All
    © 2019 All Rights Reserved.
    Powered By: Hocalwire
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok
    X
    X