Acid peptic disorder in children: impact of long-term use of Proton Pump Inhibitors
Acid peptic diseases result from a varied but superimposed pathogenic mechanism (1). They occur due to the effects of acid on diminished mucosal defence due to an imbalance between cytotoxic and cytoprotective factors in the upper gastrointestinal tract (2). The secretion of gastric acid is a continuous but complex process incorporating various pathways like the neuronal, paracrine, and endocrine (3). This secretion of hydrochloric acid with a pH between 1.0-3.5 and the kinetic tri-dimensional muscular structure, function combinedly to process the ingested food (4).