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long-term Lithium use tied to higher risk of VTE, Parkinson and kidney diseases
Sweden: A study published in BIPOLAR DISORDERS, An International Journal of Psychiatry and Neurosciences, has concluded that those prescribed lithium have lowered risk of cardiovascular and cerebrovascular disease without any marked effect on dementia compared to those who have mood or psychotic disorder not prescribed lithium.
The researchers also mentioned that individuals prescribed lithium have a higher prevalence of venous thromboembolism, Parkinson's disease, and kidney disease.
Katja Ponzer and colleagues from the Department of Molecular Medicine and Surgery at Karolinska Institute determined whether long-term lithium treatment has protective effects or a higher risk of vascular, neurological, and renal disorders.
The study summary includes the following:
- The researchers identified 9698 cases and matched 96,507 controls (general population).
- The outcomes measured in the study were vascular, neurological, renal, and suicide.
- Lithium users had a higher overall disease burden.
- Those on lithium had a 20 % lower risk of cardiovascular and cerebrovascular disorders having an HR of 0.80.
- Among lithium users, there was no significant difference for dementia, having an HR of 1.15.
- The lithium-treated patients had a 50 % higher risk of pulmonary embolism than the general population and the psychiatric subcohort, with an HR of 2.86. and 1.68, respectively.
- Parkinson's disease and kidney disease were higher in lithium users.
In Conclusion, individuals prescribed lithium have no marked effect on dementia.
Prescribed lithium has a higher prevalence of Venous thromboembolism, Parkinson's disease, and kidney disease.
This is the first and largest epidemiological studies for determining vascular, neurological and renal disorders due to long-term lithium use.
As acknowledged, the study received funding from
Söderström‐Königska Foundation.
The study's Limitations include Retrospective observational design.
Further reading:
Ponzer K, Millischer V, Schalling M, Gissler M, Lavebratt C, Backlund L. Lithium and risk of cardiovascular disease, dementia and venous thromboembolism. Bipolar Disord. 2023 Jan 18. doi: 10.1111/bdi.13300
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751