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Use of second-generation antipsychotic drugs tied to reduced risk of Covid-19 infection: JAMA
The usage of second-generation antipsychotic medicines was related with a lower incidence of COVID-19 infection in people hospitalized with significant mental illness, but valproic acid was associated with a greater risk, says an article published in the Journal of American Medical Association.
Individuals suffering from severe mental illness are at a higher risk of contracting COVID-19. Several psychotropic medicines have been discovered as possible therapeutic agents for COVID-19 prevention or treatment, although they have not been well studied in this group. As a result, Katlyn Nemani and her colleagues did this research. To investigate the relationship between the use of psychotropic drugs and the risk of COVID-19 infection in persons receiving long-term inpatient psychiatric care.
This retrospective cohort research looked at persons with significant mental illnesses who were hospitalized in New York's statewide psychiatric hospital system between March 8 and July 1, 2020. The deadline for follow-up was December 1, 2020. The research included 1958 successive adult inpatients with serious mental illness who were consistently hospitalized from March 8 to medical discharge or July 1, 2020 and were tested for SARS-CoV-2 by reverse transcriptase–polymerase chain reaction or anti nucleocapsid antibodies. Participants who had been provided psychotropic drugs previous to the COVID-19 assessment were taken into account.
The key findings of this study were as follows :
1. The study comprised 1958 (93.8%) of the 2087 adult inpatients with significant mental illness who were continuously hospitalized during the study period; 1442 (73.6%) were men, and the mean (SD) age was 51.4 (14.3) years.
2. A total of 969 patients (49.5%) developed laboratory-confirmed COVID-19 infection while hospitalized, with 38 (3.9 %) dying.
3. The usage of second-generation antipsychotic drugs as a class was linked to a lower risk of infection, while mood stabilizers were linked to a higher risk of infection.
4. In a multivariable model of individual drugs, paliperidone was related with a lower risk of infection, whereas valproic acid was associated with an increased risk of infection.
5. In unadjusted analyses, clozapine usage was linked with a lower risk of death.
In conclusion, several psychotropic medicines were linked to an increased risk of COVID-19 infection in inpatients with major mental illness; second-generation antipsychotics were linked to a lower risk, with paliperidone dosage having the biggest effect size. The usage of valproic acid was linked to an increased risk of infection.
Reference:
Nemani, K., Williams, S. Z., Olfson, M., Leckman-Westin, E., Finnerty, M., Kammer, J., Smith, T. E., Silverman, D. J., Lindenmayer, J.-P., Capichioni, G., Clelland, J., & Goff, D. C. (2022). Association Between the Use of Psychotropic Medications and the Risk of COVID-19 Infection Among Long-term Inpatients With Serious Mental Illness in a New York State–wide Psychiatric Hospital System. In JAMA Network Open (Vol. 5, Issue 5, p. e2210743). American Medical Association (AMA). https://doi.org/10.1001/jamanetworkopen.2022.10743
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Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751