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  • Asthma Linked to...

Asthma Linked to Increased Risk of Sepsis, finds Mendelian Randomized Study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-09-19T20:00:34+05:30  |  Updated On 20 Sept 2024 2:24 PM IST
Asthma Linked to Increased Risk of Sepsis, finds Mendelian Randomized Study
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According to researchers, asthma may be causally associated with an increased risk for developing sepsis. This indicates that timely preventive measures and timely intervention be given to patients with asthma. Recently, a research study using the Mendelian randomization (MR) analysis further added evidence that asthma is related to an increased risk of getting diagnosed with several types of sepsis, such as streptococcus and pneumonia-related sepsis. The research findings were published in the World Allergy Organization Journal by Jihang L. and colleagues.

Asthma is a chronic respiratory disease with characteristics of airway inflammation and hyperresponsiveness. Although some of the previous observational studies have postulated a potential association between asthma and sepsis, a clear causal link is still quite uncertain. In addressing this gap in knowledge, the current study used a genetic variant-based instrumental variable method to explore possible causal links between asthma and sepsis. This has a clear advantage over the observational studies, as it has minimum confounding effects and reduced bias.

They used asthma-associated single-nucleotide polymorphisms as instrumental variables derived from a meta-analysis involving a genome-wide association study of sufficient size. There were three methods in this MR study: inverse-variance weighted, MR-Egger regression, and weighted median analysis. The study summarized the main results with combined odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) for overall and by-type sepsis, and their relationships with asthma. We conducted sensitivity analyses regarding the validity of the instrumental variables and a potential pleiotropic bias. In addition, we performed reverse MR analysis to explore whether there was a possible directed consequence of asthma on sepsis.

Key Findings

• The study found a statistically significant relationship between asthma and increased chances of sepsis (OR=1.18, P<0.05), and the paper suggests that asthma can become a risk factor for developing sepsis.

Specific Types of Sepsis:

• Streptococcal sepsis (OR=1.23, P=0.04)

• Pneumonia-related sepsis (OR=1.57, P<0.05.

• There was no causal relationship between sepsis and asthma in the reverse MR, thus ruling out that sepsis has a contribution to the development of asthma.

The findings of the study provide evidence for asthma as a cause of increasing the risk of various types of sepsis, including those due to streptococcal and pneumococcal infections. Higher odds ratios observed in ICU settings raised the possibility of severe forms of sepsis in asthma patients. These results emphasized that early detection and management of sepsis in asthma patients can significantly reduce the risk of a severe outcome. The study also provided an important view about the relationship regarding its directionality because it did not find any reverse causality from sepsis to asthma.

Reference:

Luo, J., Liu, P., & Luo, Y. (2024). Genetic prediction of asthma increases multiple sepsis risks: A Mendelian randomization study. The World Allergy Organization Journal, 17(8), 100937. https://doi.org/10.1016/j.waojou.2024.100937

World Allergy Organization JournalAsthmasepsisMendelian randomizationgenome-wide association studycausal relationship
Source : World Allergy Organization Journal
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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