Endobronchial valve therapy for emphysema improves lung function and quality of life, finds research

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-04-17T06:15:41+05:30 | Updated On 17 April 2024 11:50 AM IST

A new study published in the Annals of the American Thoracic Society revealed the long-term efficacy of the Spiration Valve System (SVS) in treating severe heterogeneous emphysema. The EMPROVE study was conducted over a 24-month period that marks a significant advancement in understanding and managing this debilitating respiratory condition. EMPROVE trial is one of the first rigorous comparison between treatment and control groups over an extended follow-up period.

The findings from EMPROVE paint a promising picture for emphysema patients. The patients receiving SVS treatment demonstrated a remarkable and sustained improvement in lung function measured by the forced expiratory volume in 1 second (FEV1), even after 24 months. Also, significant enhancements in quality-of-life (QOL) measures were observed, including the marked improvements in respiratory symptoms and reduced dyspnea when compared to the control group.

The absence of significant adverse events associated with SVS treatment was a remarkable finding of this study. Despite the prevailing concerns about potential complications, the incidence of acute chronic obstructive pulmonary disease exacerbations and pneumothorax remained low and comparable between the treatment and control groups.

The durability of SVS treatment demonstrated in this study offers hope for the patients with emphysema who seek long-lasting relief from their symptoms. These results validate the effectiveness of endobronchial valve therapy, and also they highlight its safety and potential to transform the management of severe emphysema.

Research:

Criner, G. J., Mallea, J. M., Abu-Hijleh, M., Sachdeva, A., Kalhan, R., Hergott, C. A., Lazarus, D. R., Mularski, R. A., Calero, K., Reed, M. F., Nsiah-Dosu, S., Himes, D., Kubo, H., Kinsey, C. M., Majid, A., Hogarth, D. K., Kaplan, P. V., Case, A. H., Makani, S. S., … Shepherd, R. W. (2024). Sustained Clinical Benefits of Spiration Valve System in Patients with Severe Emphysema: 24-Month Follow-Up of EMPROVE. In Annals of the American Thoracic Society (Vol. 21, Issue 2, pp. 251–260). American Thoracic Society. https://doi.org/10.1513/annalsats.202306-520oc

Source : Annals of the American Thoracic Society

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751