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  • Hyaluronic acid may...

Hyaluronic acid may predict severity & prognosis of community-acquired pneumonia: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 15 Jan 2025 3:30 PM  |  Updated On 16 Jan 2025 6:48 AM
Hyaluronic acid may predict severity & prognosis of community-acquired pneumonia: Study
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Hyaluronic acid (HA) has emerged as a promising biomarker for assessing the severity & prognosis of community-acquired pneumonia (CAP), showing strong diagnostic accuracy (AUC: 0.709) as published in the Journal of Inflammation Research.

Hyaluronic acid (HA) is a novel inflammatory biomarker with a prognostic value for several infectious diseases. This study investigated the association of Hyaluronic acid with severity and prognosis in hospitalized patients with community-acquired pneumonia (CAP).

They analyzed the differences of Hyaluronic acid levels in different groups. Logistic regression analysis was performed to identify independent risk factors for severe CAP (SCAP). The predictive value of Hyaluronic acid for SCAP was assessed using receiver operating characteristic (ROC) curves. Kaplan-Meier survival analysis was used to compare 30-day mortality between the high and low Hyaluronic acid groups. Results: Compared to healthy controls (49.2 ± 15.3 ng/mL), patients with CAP exhibited significantly elevated levels of Hyaluronic acid(P < 0.001).

In CAP patients, increased Hyaluronic acidlevels were more pronounced in those with SCAP (SCAP vs non-SCAP:135.6 ± 51 ng/mL vs 100.7 ± 47.8 ng/mL, P < 0.001). Compared to survivors (109.9 ± 48.7 ng/mL), Hyaluronic acid levels in non-survivors were significantly higher (180.9 ± 67.8 ng/mL) (P < 0.001). Hyaluronic acid was an independent predictor of SCAP [odds ratio (OR): 1.013, 95% confidence interval (CI): 1.003– 1.022, P = 0.011] with high diagnostic accuracy [areas under the curve (AUC): 0.709, 95% CI: 0.622– 0.797, P = 0.001].

Additionally, Hyaluronic acid was independently associated with death risk in patients with CAP (OR: 1.022, 95% CI: 1.005– 1.039, P = 0.010). Kaplan-Meier survival curves indicated that CAP patients in the high HA group exhibit a higher 30-day mortality rate compared to those in the low Hyaluronic acid group (8.6% vs 1.5%, P = 0.008).

Post hoc analysis indicated that our study possessed 98.857% statistical power. In conclusion, High Hyaluronic acid levels are associated with severity and mortality in patients with CAP, and Hyaluronic acid could serve as a novel serum biomarker to predict the risk of CAP progression.

Reference:

Lin Y, Li Y, Cui X, Zhu N, Li X. Hyaluronic Acid is Associated with Severity and Prognosis in Patients with Community-Acquired Pneumonia. J Inflamm Res. 2024;17:11881-11895https://doi.org/10.2147/JIR.S499326

Hyaluronic acidpredictseverityprognosiscommunity-acquired pneumoniastudy
Source : Journal of Inflammation Research
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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