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Increased odds of cardiovascular and premature death encountered among COPD and Asthma patients

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-01-07T10:15:21+05:30  |  Updated On 7 Jan 2023 1:21 PM IST
Increased odds of cardiovascular and premature death encountered among COPD and Asthma patients
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Finland: A new research found that increased mortality due to cardiovascular disease and premature death has been found in patients with asthma and chronic obstructive pulmonary disease patients. The study results were published in the journal Respiratory Medicine.

Asthma and chronic obstructive pulmonary disease (COPD) are globally underdiagnosed, obstructive airway diseases with different pathophysiology and patient characteristics that caused increased morbidity and mortality. The mortality in asthma is dependent on factors like smoking status, lung function, and exacerbations, and other comorbidities while the mortality in COPD is due to the severity of obstruction, decreased forced expiratory volume per 1 s, systemic inflammation. Tiina Matilla et al from Helsinki, Finland conducted a study to understand the comorbidities of asthma, COPD, and asthma-COPD overlap (ACO) and reported the total and cause-specific mortality over an 18-year follow-up.

Also Read: Specific outdoor air pollutants linked to asthma attacks in urban children by NIH study

A national health examination survey was carried out on Finnish adults aged ≥30 years in 2000–2001. Nearly 5922 participants (73.8% of the sample) with all relevant data, including a comprehensive clinical examination and spirometry, were included in the study cohort. The total, cardiovascular, cancer, and respiratory mortality were recorded through a record linkage by following the patients from baseline until the end of 2018. Survey data, including spirometry and register data, were used to define asthma, COPD, and ACO. There were three separate groups of obstructive subjects (one definition excluding the others).

Key findings of the study:

  • In Cox's model adjusted for sex, age, smoking, education level, BMI, leisure time physical activity, cardiovascular disease, diabetes, and hypertension it was found that asthma and COPD were significantly associated with higher total mortality.
  • Hazard ratios (HR) for asthma, COPD, and ACO were 1.29, 1.50, and 1.26 respectively.
  • Asthma and COPD were associated with cardiovascular mortality.
  • There was a significant association with mortality risk among those with hs-CRP 1–2.99 mg/l even though ACO did not predict mortality in the whole cohort.
Also Read: Depression in asthmatic patients associated with increased airway obstruction: Study

Thus, this Finnish national health survey found that having asthma or COPD at baseline predicted mortality especially due to cardiovascular diseases during an 18-year follow-up.

Further reading: Mattila T, Vasankari T, Kauppi P, Mazur W, Härkänen T, Heliövaara M. Mortality of asthma, COPD, and asthma-COPD overlap during an 18-year follow up [published online ahead of print, 2022 Dec 31]. Respir Med. 2022;107112. doi: 10.1016/j.rmed.2022.107112

Respiratory MedicineAsthmaCOPDPulmonology
Source : Respiratory Medicine
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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