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Live vaccinations safe and effective among patients taking Dupilumab, reveals Study
The new advancement published in the recent issue of the Annals of Allergy, Asthma & Immunology unveiled promising insights into the safety of vaccinations for patients receiving dupilumab, a monoclonal antibody known for its efficacy in treating a variety of conditions. Dupilumab targets the interleukin (IL)-4 receptor alpha subunit to effectively block the inflammatory effects of IL-4 and IL-13, this makes it a valuable treatment for diseases such as asthma, atopic dermatitis, and eosinophilic esophagitis.
Previously, clinical trials that involved dupilumab have taken a cautious approach by excluding patients from receiving live vaccines. This precaution was reflected in the package insert that advises against administering live vaccines to individuals who undergo treatment with dupilumab. This recommendation was to prevent any potential adverse effects stemming from the immune-modulating properties of the drug. The recent approval of dupilumab use in treating atopic dermatitis in patients as young as six months has raised concerns on the pediatric patients who typically follow a vaccination schedule that includes live vaccines.
To address this, Jay Lieberman and team undertook this comprehensive systematic review of existing literature to assess the safety and efficacy of vaccinations, particularly live vaccines, in patients treated with dupilumab. The systematic review analyzed data from various studies involving patients who received vaccinations while on dupilumab. The outcomes found that overall, live vaccines were safe for patients on dupilumab and the efficacy of these vaccines was generally not compromised by the medication. This conclusion was further supported by the expert Delphi Panel, which reached a consensus that the use of vaccines in patients on dupilumab is likely both safe and effective.
Thereby, the recommendation for avoiding live vaccines in patients treated with dupilumab may need to be reconsidered. But, a shared decision-making approach is advised to ensure that patients continue to receive necessary immunizations without undue delay, to maintain their overall health and protect against preventable diseases.
Reference:
Lieberman, J. A., Chu, D. K., Ahmed, T., Dribin, T. E., Abrams, E. M., Anagnostou, A., Blumenthal, K. G., Boguniewicz, M., Chase, N. M., Golden, D. B., Hartog, N. L., Heimall, J. R., Ho, T., Lawrence, M. G., Khan, D. A., Minniear, T. D., Mustafa, S. S., Oppenheimer, J. J., Phillips, E. J., … Greenhawt, M. J. (2024). Use of Vaccines in Patients Receiving Dupilumab, A Systematic Review and Expert Delphi Consensus Recommendation: A position paper of the American College of Allergy, Asthma and Immunology. In Annals of Allergy, Asthma & Immunology. Elsevier BV. https://doi.org/10.1016/j.anai.2024.05.014
Neuroscience Masters graduate
Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751