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Rheumatoid Arthritis and Osteoarthritis patients genetically susceptible for developing COPD, suggests study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-04-26T20:30:18+05:30  |  Updated On 27 April 2024 11:47 AM IST
Rheumatoid Arthritis and Osteoarthritis patients genetically susceptible for developing COPD, suggests study
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Rheumatoid Arthritis and Osteoarthritis patients are genetically susceptible to developing COPD, suggests a study published in the Frontiers in Medicine.

Observational studies have reported that chronic obstructive pulmonary disease (COPD) is often accompanied by autoimmune diseases, but the causal relationships between them remain uncertain. In this Mendelian study, we aimed to investigate the potential causal relationship between COPD and four common autoimmune diseases. They analyzed summary data on COPD and autoimmune disease using publicly available genome-wide association studies (GWAS) summary data. We initially employed the inverse-variance weighted method as the primary approach to establish the causal impact of COPD on autoimmune diseases in the sample and conducted additional sensitivity analyses to examine the robustness of the results. Subsequently, we performed reverse Mendelian randomization (MR) analyses for the four autoimmune diseases. Finally, the potential for bidirectional causal relationships was assessed.

Results: The MR analysis revealed no significant causal relationship between COPD and any of the studied autoimmune diseases. However, reverse MR results indicated a significant association between rheumatoid arthritis (RA), osteoarthritis (OA) and the risk of developing COPD, with respective odds ratios (OR) of 377.313 (95% CI, 6.625–21487.932, P = 0.004) for RA and 11.097 (95% CI, 1.583–77.796, P = 0.015) for OA. Sensitivity analyses confirmed the robustness of the results. The findings support a potential causal relationship between autoimmune diseases and COPD, highlighting the importance of considering comorbidities in clinical management of COPD.

Reference:

Yu X, Cheng X, Lv L, Wang N, Li M, Ji W, Liu T, Wang G, Hu T, Shi Z. The association between chronic obstructive pulmonary disease and autoimmune diseases: a bidirectional Mendelian randomization study. Front Med (Lausanne). 2024 Mar 5;11:1331111. doi: 10.3389/fmed.2024.1331111. PMID: 38504914; PMCID: PMC10949139.

Rheumatoid ArthritisOsteoarthritis patientssusceptibleCOPDstudy
Source : Frontiers in Medicine
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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