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  • Sarcoidosis associated...

Sarcoidosis associated with greater risk of venous thromboembolism, claims study

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-04-28T21:00:09+05:30  |  Updated On 29 April 2024 11:15 AM IST
Sarcoidosis associated with greater risk of venous thromboembolism, claims study
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Researchers have found in a nationwide cohort study that Sarcoidosis was associated with long-term risk of venous thromboembolism.

A growing body of evidence implies that Chronic inflammation is a precursor to venous thromboembolism (VTE). However, unlike other inflammatory conditions such as systemic lupus erythematosus and rheumatoid arthritis, data on the risk of VTE in individuals with sarcoidosis are scarce.

Do individuals with sarcoidosis have a greater long-term risk of developing VTE (pulmonary embolism or deep venous thrombosis) compared to the general population?
Danish nationwide registries were used. Patients >18 years with newly diagnosed sarcoidosis (>2 in/outpatient visits, 1996-2020) without prior VTE were matched 1:4 by age, sex, and comorbidities with individuals from the background population. Venous thromboembolism was the primary outcome.
Key findings from the study are:
· 14,742 patients with sarcoidosis and 58,968 matched individuals of median age 44.7 years were included.
· Of these patients, 57.2% were males.
· The median follow-up duration was 8.8 years.
· The absolute 10-year risks of VTE, pulmonary embolism, and deep venous thrombosis for patients with sarcoidosis were 2.9%, 1.5%, and 1.6%, respectively, compared to 1.6%, 0.7%, and 1.0% in the background population.
· Sarcoidosis was associated with an increased rate of all outcomes in the first year after diagnosis and after the first year compared with the background population.
· Excluding cancer patients and censoring those with incident cancer, the associations persisted.
· Three-month mortality was not significantly different between VTE patients with and without sarcoidosis (adjusted HR 0.84)

The occurrence of VTE during sarcoidosis is associated with a more severe disease and a poorer prognosis. The occurrence of VTE during sarcoidosis might signal a more inflammatory and/or evolutive disease in sarcoidosis/VTE patients and should be taken in consideration when designing therapeutic strategies for them.

In this nationwide cohort study, sarcoidosis was associated with an increased long-term risk of developing venous thromboembolism (VTE) compared to a matched background population.
Reference:
Yafasova A et al. Long-term risk of venous thromboembolism in sarcoidosis: a nationwide cohort study. Chest. 2024 Jan 29:S0012-3692(24)00134-X. doi: 10.1016/j.chest.2024.01.042.
Cohort studylong-termsarcoidosisvenous thromboembolism.Danish nationwide registries
Source : CHEST journal
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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