- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Tobramycin inhalation may decrease flares of non-cystic fibrosis bronchiectasis: Study
Non-cystic fibrosis (CF) patients with bronchiectasis usually develop chronic bronchial infection with Pseudomonas aeruginosa (PA) that is related to worsening lung function and increased morbidity and mortality.
Non-cystic fibrosis bronchielctasis patients when assigned tobramycin inhalation solution once daily had a nonsignificant decrease in the number of exacerbations compared with a placebo, according to recent research.
Bronchiectasis is usually divided by that caused by cystic fibrosis (CF) and non-cystic fibrosis, however, previous studies revealed that in patients with stable non-CF bronchiectasis, 13 to 31 percent develop infections with Pseudomonas aeruginosa.
There is currently less experience with inhaled tobramycin in non-cystic fibrosis bronchiectasis than in cystic fibrosis (CF) but intravenous formulation and solution for inhalation (TSI) have been studied in non-CF bronchiectasis patients with chronic P. aeruginosa bronchial infection. In non-cystic fibrosis bronchiectasis, studies with inhaled antibiotics are limited
"Tobramycin inhalation solution with other inhaled antibiotics are part of the standard care in cystic fibrosis and especially in patients with pseudomonas aeruginosa colonization," Lotte C. Terpstra, Ph.D., of the department of pulmonology at Alkmaar Medical Center in the Netherlands, said during a presentation at the virtual European Respiratory Society International Congress.
Researchers conducted a randomized, double-blind, placebo-controlled, multicenter trial to investigate the efficacy and safety of inhaled tobramycin solution (Pfizer) in 58 patients with confirmed non-cystic fibrosis bronchiectasis and at least two exacerbations in the past year and positive sputum culture. Patients were randomly assigned to tobramycin inhalation solution maintenance treatment (n = 26) or placebo (n = 26) for 1 year.
The authors were aiming to achieve a 50% reduction in the number of exacerbations on maintenance tobramycin compared with the placebo. Also, the secondary endpoints were time to first exacerbation, lung function change, quality of life, sputum density and safety.
The following findings were highlighted-
- A nonsignificant decrease in the number of bronchiectases exacerbations of 3.81 to 1.58 in patients treated with tobramycin compared with a decrease of 3.9 to 2.2 exacerbations for those treated with placebo
- A 26% risk reduction for tobramycin inhalation solution.
As a result, the authors concluded that "Although the primary endpoint was not significantly reached, this study showed that tobramycin inhalation solution once daily is a treatment option for bronchiectasis patients with frequent exacerbations infected by different pathogens."
BDS, MDS( Pedodontics and Preventive Dentistry)
Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751