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  • Decoding REGEN-COV2...

Decoding REGEN-COV2 for Mild to Moderate SARS-CoV-2 Infection in Kidney Transplant Recipients

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2022-03-17T11:45:34+05:30  |  Updated On 2022-03-17T11:24:58+05:30
Decoding REGEN-COV2 for Mild to Moderate SARS-CoV-2 Infection in  Kidney Transplant Recipients
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Kidney transplant recipients are an immunocompromised population, with comorbid conditions such as obesity, diabetes, and coronary artery disease, which increases their risk for progressing to severe COVID-19. Although COVID-19 vaccination is currently widespread and recommended for the prevention of severe COVID-19 infection, some transplant programs delay administering vaccinations immediately post-transplant to avoid all immune stimulation. Also, immunosuppressed kidney transplant recipients may have impaired antibody responses.

In the current study, REGN-COV2 was administered to 14 kidney transplant recipients with mild to moderate COVID-19 infection. To be eligible for REGN-COV2, all recipients must test positive by nasopharyngeal swab for SARS-CoV-2 via RT-PCR.

Results

Baseline Characteristics

  • The median age of treated recipients was 62 years (IQ range 52-69), and the median time from transplant was 5 years (IQ range 1-9)
  • Preexisting risk factors for the severe disease were identified in our recipients and included age > 65 years, hypertension, coronary disease, and diabetes mellitus.
  • The median time to REGN-COV2 infusion was 5 days (interquartile range 4-7).
  • 3/14 recipients received corticosteroid maintenance therapy. Overall, immunosuppression was reduced in 6 patients after COVID-19 diagnosis.

Safety

  • A single REGN-COV2 infusion of casirivimab 1200 mg and imdevimab 1200 mg was tolerated by our kidney transplant recipients.
  • No cases of hypersensitivity reactions were observed.
  • During infusion, 1 adverse event occurred where a recipient complained of burning sensation in the hands, which resolved following a dose of acetaminophen.
  • 1 individual, aged 61 years, was hospitalized 6 days after infusion for worsening symptoms and required supplemental oxygen. This patient received dexamethasone, remdesivir, and tocilizumab, and up to 15 L oxygen. Further, the patient continued to improve and no longerneed oxygen supplement 2 weeks after discharge.

Efficacy

In kidney transplant recipients who are unable to obtain or have impaired antibody response to vaccinations, timely administration of REGN-COV2 in COVID-19–positive kidney transplant recipients may prevent progression to severe illness.

Conclusion:
Neutralizing antibody therapy with REGN-COV2 was well tolerated and will continue to be useful in kidney transplant recipients with mild to moderate COVID-19 regardless of vaccination status.
To know more about prescribing information, click here.

Reference:

Liu EC, Lee JH, Loo A, MazurS, Sultan S, Aull M, Lee JB, MuthukumarT, Hartono C. Casirivimab-Imdevimab (REGN-COV2) for Mild to Moderate SARS-CoV-2 Infection in Kidney Transplant Recipients. Kidney Int Rep. 2021 Nov;6(11):2900-2902.

Disclaimer: This content and information provided is intended for update strictly for registered medical practitioners/ Physicians treating Covid 19 only. The information mentioned herein is not intended nor implied to be a substitute for professional medical advice. Any advice regarding the management of any medical condition is totally in the discretion of doctor (Registered Medical Practitioner)/ physician treating Covid 19 patients. Prescription of the drug is the prerogative of doctors (Registered Medical Practitioner/ Physician treating Covid 19) at his /her sole discretion. Physicians treating Covid 19 patients must refer to the full prescribing information of the product for use of product. Copying, reproduction, circulation of the information published here in any form or by any means either mechanically/ print or electronically without prior consent is strictly prohibited. Any unauthorised person having possession of this document should discard the same or inform/ notify/ return to Cipla Ltd. To report any adverse events/special situations with Cipla medicinal products email at drugsafety@cipla.com. or via the national Pharmacovigilance Programme of India by calling on 1800267 7779 (Cipla number) or you can report to PvPI on 1800 180 3024. By reporting side effects, you can help provide more information on the safety of this product. For complete prescribing information, please login www.ciplamed.com

kidney transplant sars-cov2 Covid‐19 imdevimab casirivimab ronapreve regen cov 
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues section. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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