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  • 18F-FCH-PET has...

18F-FCH-PET has superior sensitivity than ultrasound or sestamibi for parathyroid localization: Study

Dr. Shravani DaliBy Dr. Shravani DaliPublished On 2021-08-09T20:15:51+05:30  |  Updated On 2021-08-09T20:15:57+05:30
18F-FCH-PET has superior sensitivity than ultrasound or sestamibi for parathyroid localization: Study

The use of 18F-fluorocholine positron emission tomography for parathyroid localization within the first cohort in the United States is better in terms of sensitivity than ultrasound or sestamibi, suggests a study published in the Surgery. Preoperative parathyroid imaging helps the surgeons during parathyroidectomy. A study conducted by Graves C et. al assess the clinical influence...

The use of 18F-fluorocholine positron emission tomography for parathyroid localization within the first cohort in the United States is better in terms of sensitivity than ultrasound or sestamibi, suggests a study published in the Surgery.

Preoperative parathyroid imaging helps the surgeons during parathyroidectomy. A study conducted by Graves C et. al assess the clinical influence of 18F-fluorocholine positron emission tomography for preoperative parathyroid localization on patients suffering from primary hyperparathyroidism.

The researchers selected patients with primary hyperparathyroidism and indications for parathyroidectomy had simultaneous 18F-fluorocholine positron emission tomography imaging/magnetic resonance imaging. In patients who underwent subsequent parathyroidectomy, treatment was based on lab values at least 6 months after surgery. Location-based sensitivity and specificity of 18F-fluorocholine positron emission tomography imaging was assessed using 3 anatomic locations (left neck, right neck, and mediastinum), with surgery as the gold standard.

The results of the study are as follows:

· Among the total 101 patients, 18F-fluorocholine positron emission tomography localized at least 1 candidate lesion in 93% of patients overall and in 91% of patients with previously negative imaging, leading to a change in preoperative strategy in 60% of patients.

· Of 76 patients who underwent parathyroidectomy, 58 (77%) had laboratory data at least 6 months postoperatively, with 55/58 patients (95%) demonstrating cure.

· 18F-fluorocholine positron emission tomography successfully guided curative surgery in 48/58 (83%) patients, compared with 20/57 (35%) based on ultrasound and 13/55 (24%) based on sestamibi.

· In a location-based analysis, the sensitivity of 18F-fluorocholine positron emission tomography (88.9%) outperformed both ultrasound (37.1%) and sestamibi (27.5%), as well as ultrasound and sestamibi combined (47.8%).

The researchers concluded that among the first cohort in the United States the use of 18F-fluorocholine positron emission tomography for parathyroid localization confirm its utility in a challenging cohort, with better sensitivity than ultrasound or sestamibi.

Reference:

Superior sensitivity of 18F-fluorocholine: PET localization in primary hyperparathyroidism by Graves C et. al published in the Surgery.

DOI: https://doi.org/10.1016/j.surg.2021.05.056


18f- fch-pet sensitivity surgery primary hyperparathyroidism parathyroid localization ultrasound sestamibi 
Source : SURGERY
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences.

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