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  • Clear cell likelihood...

Clear cell likelihood score derived from MRI, correlates with renal mass growth rate: Study

Dr. Kamal Kant KohliBy Dr. Kamal Kant KohliPublished On 2021-07-31T09:00:12+05:30  |  Updated On 2021-07-31T09:00:33+05:30
Clear cell likelihood score derived from MRI, correlates with renal mass growth rate: Study

non-invasive clear cell likelihood score (ccLS)--derived from MRI--correlates with the growth rate of small renal masses

Leesburg: According to ARRS' American Journal of Roentgenology (AJR), the standardized non-invasive clear cell likelihood score (ccLS)--derived from MRI--correlates with the growth rate of small renal masses (cT1a, <4 cm) and may help guide personalized management.Extracted from clinical reports, "the ccLS scores the likelihood that the small renal mass represents clear cell renal...

Leesburg: According to ARRS' American Journal of Roentgenology (AJR), the standardized non-invasive clear cell likelihood score (ccLS)--derived from MRI--correlates with the growth rate of small renal masses (cT1a, <4 cm) and may help guide personalized management.

Extracted from clinical reports, "the ccLS scores the likelihood that the small renal mass represents clear cell renal cell carcinoma, from 1 (very unlikely) to 5 (very likely)," explained corresponding author Ivan Pedrosa from the University of Texas Southwestern Medical Center at Dallas. "Small renal masses with lower ccLS may be considered for active surveillance, whereas small renal masses with higher ccLS may warrant earlier intervention."

Pedrosa and colleagues' retrospective study included consecutive small renal masses assigned a ccLS on clinical MRI examinations performed between June 2016 and November 2019 at an academic tertiary-care medical center or its affiliated safety net hospital system. Tumor size measurements were extracted from available prior and follow-up cross-sectional imaging examinations, through June 2020.

Among 389 small renal masses in 339 patients (198 men, 141 women; median age, 65 years) on active surveillance that were assigned a ccLS on clinical MRI examinations, those with ccLS4-5 grew significantly faster (9% diameter, 29% volume yearly) than those with ccLS1-2 (5% diameter, p<.001; 16% volume, p<.001) or ccLS3 (4% diameter, p<.001; 15% volume, p<.001).

Noting that the lack of validated imaging markers to characterize biologic aggressiveness of small renal masses hinders medical decision making among available initial management strategies, "growth is associated with ccLS in small renal masses," the authors of this AJR article reiterated, "with higher ccLS correlating with faster growth."

For further references log on to:

http://dx.doi.org/10.2214/AJR.21.25979

American Journal of Roentgenology 
Source : American Journal of Roentgenology
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues section. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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