Medical Dialogues
  • Dermatology
Sign in Signup
This site is intended for healthcare professionals only
Sign in Signup
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
Medical Dialogues
  • Medical News
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Medical Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
  • MDTV
      • Anesthesia
      • CTVS
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • Diet and nutrition
      • ENT
      • Gastroenterology
      • Health Dialogues
      • Health News today
      • Health Shorts
      • Health Updates
      • Health video of the day
      • Laboratory Medicine
      • Latest Videos
      • Latest Webinars
      • MD shorts
      • Medical News Today
      • Medical Updates
      • Medical Video of the day
      • Medicine
      • Nephrology
      • Neurology and Neurosurgery
      • Obstetrics and Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics & Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Top Videos
      • Urology
This site is intended for healthcare professionals only
Sign InRegister
Medical Dialogues
Sign inRegister
  • Home
  • Medical news
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Medical Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
  • Case of the Day
  • Editorial
  • Home
  • Radiology
  • Radiology News
  • PET/CMR may help in...

PET/CMR may help in accurate detection of left atrial appendage thrombus: Study

MD Editorial TeamBy MD Editorial TeamPublished On 2021-11-08T09:00:14+05:30  |  Updated On 2021-11-08T09:00:32+05:30
PET/CMR may help in accurate detection of left atrial appendage thrombus: Study

USA: PET/CMR of [64Cu] FBP8 may identify both acute and older platelet-poor thrombi with high accuracy, finds a new study. Moreover integrated PET/CMR approach provides useful information on the biological properties of left atrial appendage such as fibrin and methemoglobin content.The study was published in the journal JACC: Cardiovascular Imaging on 13th October 2021.Detecting thrombus in...

USA: PET/CMR of [64Cu] FBP8 may identify both acute and older platelet-poor thrombi with high accuracy, finds a new study. Moreover integrated PET/CMR approach provides useful information on the biological properties of left atrial appendage such as fibrin and methemoglobin content.

The study was published in the journal JACC: Cardiovascular Imaging on 13th October 2021.

Detecting thrombus in the left atrial appendage (LAA) is critical in stroke prevention and is presently done through transesophageal echocardiography (TEE). David Izquierdo-Garci and team aimed to detect and characterize LAA thrombus in humans using combined positron emission tomography (PET)/cardiac magnetic resonance (CMR) of a fibrin-binding radiotracer, [64Cu]FBP8.

In 8 healthy subjects, the metabolism and pharmacokinetics of [64Cu] FBP8 were investigated. Patients with atrial fibrillation and recent TEEs of the LAA (positive n = 12; negative n = 12) were injected with [64Cu] FBP8 and scanned with PET/CMR, including measuring the LAA's longitudinal magnetic relaxation time (T1).

SUV max values in the LAA were considerably greater in individuals with clots in the LAA than in those who did not have clots in the LAA. According to the researchers, an SUV max threshold of 2.6 produced a sensitivity of 100 percent and a specificity of 84 percent when reviewed by a radiologist with 15 years of expertise. Furthermore, the blood clots caused by the occlusion device implantation were quite visible. All of the blood clots in these individuals were restricted to the LAA, which was behind the device, and there was no indication of contact between the LAA and the left atrium on pictures. An examination of cardiac MRI with T1 mapping in individuals with positive ultrasound tests indicated the presence of a hyperintense signal consistent with LAA blood clots.

In conclusion, the combined PET/MRI technique offered valuable information on the biological features of blood clots, such as fibrin and methemoglobin, a clot consequence. More research is needed to assess the sensitivity of Cu-64 FBP8 for chronic thrombi (those lasting more than 10 weeks), the value of adding a gadolinium-based contrast agent to aid identification, and the embolic danger of these fibrin-poor organised thrombi.

Reference:

Izquierdo-Garcia, D., Désogère, P., Philip, A. L., Mekkaoui, C., Weiner, R. B., Catalano, O. A., Iris Chen, Y.-C., DeFaria Yeh, D., Mansour, M., Catana, C., Caravan, P., & Sosnovik, D. E. (2021). Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance. In JACC: Cardiovascular Imaging. Elsevier BV. https://doi.org/10.1016/j.jcmg.2021.08.009


MRI thrombosis PET/ CMR JACC 
Source : Journal of the American College of Cardiology
MD Editorial Team
MD Editorial Team

    Medical Dialogues consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Review: Efficacy of Antiviral Agents Against  Omicron Subvariant BA.2

    Review: Efficacy of Antiviral Agents Against Omicron Subvariant BA.2

    Choice of Antibiotics in Common Infections: Doxycycline or Azithromycin?

    Choice of Antibiotics in Common Infections: Doxycycline or Azithromycin?

    Role of acyclovir in Management of chickenpox: Analyzing the importance of starting early

    Role of acyclovir in Management of chickenpox: Analyzing the importance of starting early

    Parkinsonism and the place of Amantadine - Review Analysis

    Parkinsonism and the place of Amantadine - Review Analysis

    When to Introduce time tested drug Amlodipine to manage Hypertension?

    When to Introduce time tested drug Amlodipine to manage Hypertension?

    View All

    Journal Club Today

    Quitting Smoking After Lung Cancer Diagnosis Worth Doing

    Quitting Smoking After Lung Cancer Diagnosis Worth Doing

    View All

    Health News Today

    Health Bulletin 17/May/2022

    Health Bulletin 17/May/2022

    View All
    © 2019 All Rights Reserved.
    Powered By: Hocalwire
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok
    X
    X