Symmetric CTA collaterals may identify stroke patients likely to benefit from late thrombectomy: Study
Delhi: CT angiography (CTA) can identify stroke patients who will likely benefit from endovascular thrombectomy (EVT) to restore blood flow by showing a strong link between ischemic core growth and blood flow in the brain's collateral blood vessels, according to a recent study. The symmetric collateral pattern at CT angiography was found to be common and highly specific for low ischemic...
Delhi: CT angiography (CTA) can identify stroke patients who will likely benefit from endovascular thrombectomy (EVT) to restore blood flow by showing a strong link between ischemic core growth and blood flow in the brain's collateral blood vessels, according to a recent study. The symmetric collateral pattern at CT angiography was found to be common and highly specific for low ischemic core growth rate and small 24-hour ischemic core volume as assessed at diffusion-weighted MRI in patients with large vessel occlusion.
"After further outcome studies, collateral status at presentation may prove useful in triage for endovascular thrombectomy, especially when MRI and CT perfusion are unavailable," the researchers wrote in the journal Radiology.
Previous studies have shown that understanding ischemic core growth rate (IGR) is important for identifying patients with slow-progressing large vessel occlusion (LVO) stroke who may benefit from delayed EVT. Aneesh B. Singhal and colleagues aimed to evaluate whether symmetric collateral pattern at CTA can help to identify patients with low IGR and small 24-hour diffusion-weighted MRI ischemic core volume in patients with LVO not treated with reperfusion therapies.
Patients with anterior proximal LVO not treated with reperfusion therapies were evaluated in this secondary analysis of clinical trial data from before EVT became standard of care from January 2007 to June 2009. All patients underwent admission CTA and at least three MRI examinations at four-time points over 48 hours. The researchers categorized arterial phase CTA collaterals at presentation as symmetric, malignant, or other. Diffusion-weighted MRI ischemic core volume and IGR at multiple time points were determined. The IGR at presentation was defined as follows: (ischemic core volume in cubic centimeters)/(time since stroke symptom onset in hours).
A total of 31 patients (median age, 71 years; 19 men) were evaluated with median National Institutes of Health Stroke Scale (NIHSS) score of 13.
Key findings include:
- Collaterals were symmetric (45%; 14 of 31), malignant (13%; four of 31), or other (42%; 13 of 31).
- Median ischemic core volume was different between collateral patterns at all time points. Presentation was as follows: symmetric, 16 cm3; other, 69 cm3; and malignant, 104 cm3.
- At 24 hours, median ischemic core volumes were as follows: symmetric, 28 cm3; other, 156 cm3; and malignant, 176 cm3.
- Median IGR was also different, and most pronounced at presentation: symmetric, 4 cm3 per hour; other, 17 cm3 per hour; and malignant, 20 cm3 per hour.
- After multivariable adjustment, independent determinants of higher presentation IGR included only higher NIHSS (parameter estimate [β = 0.20) and worse collaterals (β = –2.90).
- The only independent determinant of 24-hour IGR was worse collaterals (β = –2.03).
- Symmetric collaterals had sensitivity of 87% (13 of 15) and specificity of 94% (15 of 16) for 24-hour ischemic core volume less than 50 cm3 (area under the receiver operating characteristic curve, 0.92).
The researchers concluded, "After further outcome studies, collateral status at presentation may prove useful in triage for endovascular thrombectomy, especially when MRI and CT perfusion are unavailable."
Reference:
The study titled, "Symmetric CTA Collaterals Identify Patients with Slow-progressing Stroke Likely to Benefit from Late Thrombectomy," is published in the journal Radiology.
DOI: https://pubs.rsna.org/doi/10.1148/radiol.2021210455
