Administration of ibuprofen tied to pain relief comparable to morphine and paracetamol after supratentorial brain tumors surgery: Study
Patients experience mild to moderate pain following supratentorial brain surgery. Pain-management approaches, including narcotics, are an integral part of treatment regimens that are associated with respiratory complications or seizures. The treatment should aim at pain reduction and patient satisfaction.
An investigation published in Anesthesiology and Pain Medicine found that Ibuprofen administration resulted in comparable pain relief and patient satisfaction to morphine and paracetamol, with no impact on blood clotting functions post-surgery for supratentorial brain tumors.
This clinical trial assessed pain and satisfaction in 50 patients undergoing surgery for supratentorial brain neoplasm. Group I received 400 mg of ibuprofen (intravenously) over 30 minutes after lesion removal, while Group II received morphine 0.07 mg/kg intravenously with 1000 mg paracetamol. Pain levels and satisfaction were then evaluated.
Key findings of the study are:
- In the ibuprofen group and other groups, Patients' satisfaction scores in the first 6 hours were 1.67 ± 0.72 and 2.27 ± 0.7, respectively.
- VAS mean in the first, second, third, and fourth hours was not statistically different.
- In the platelet function analysis, the measured items between the two groups were not significantly different during the three measurement periods.
In conclusion, they said that ibuprofen produced equivalent levels of pain relief and patient satisfaction as morphine and paracetamol without any negative consequences on blood clotting functions post-operatively for patients with supratentorial brain tumors.
Reference:
Salimi, Sohrab, et al. "Evaluation of Intravenous Infusion of Ibuprofen With Paracetamol-Morphine in Pain and Satisfaction of Patients Undergoing Supratentorial Brain Surgery." Anesthesiology and Pain Medicine, vol. 13, no. 5, 2023, pp. e139758.
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