During liver transplantation in HCC patients Intraoperative Blood Salvage safe and effective

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-01T20:00:55+05:30 | Updated On 1 Sept 2022 8:01 PM IST

The use of Intraoperative Blood Salvage during liver transplantation for hepatocellular carcinoma patients is a safe procedure suggests a recent study published in the Annals of Surgery

The effects of intraoperative blood salvage (IBS) on time to tumour recurrence, disease-free survival and overall survival in hepatocellular carcinoma (HCC) patients undergoing liver transplantation were assessed to evaluate the safety of IBS.

IBS is highly effective to reduce the use of allogeneic blood transfusion. However, the safety of IBS during liver transplantation for patients with HCC is questioned due to fear of disseminating malignant cells.

Comprehensive searches through June 2021 were performed in 8 databases. The methodological quality of included studies was assessed using the Robins-I tool. Meta-analysis with the generic inverse variance method was performed to calculate pooled hazard ratios (HRs) for disease-free survival, HCC recurrence and overall survival.

Results:

Nine studies were included.
Use of IBS during liver transplantation was not associated with impaired disease-free survival not associated with increased HCC recurrence and not associated with impaired overall survival

Based on available observational data, the use of IBS during liver transplantation in patients with HCC does not result in impaired disease-free survival, increased HCC recurrence or impaired overall survival. Therefore, the use of IBS during liver transplantation for HCC patients is a safe procedure.

Reference:

Aijtink, Virginia J. MD*; Rutten, Vera C. MD*; Meijer, Beatrice E.M. MD*; de Jong, Renate MD, PhD†; Isaac, John L. MD‡; Polak, Wojciech G. MD, PhD*; Perera, M. Thamara P.R. MD, FRCS§,∥; Sneiders, Dimitri MD, PhD*,§; Hartog, Hermien MD, PhD§,∥. Safety of Intraoperative Blood Salvage During Liver Transplantation in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-analysis. Annals of Surgery: August 2022 - Volume 276 - Issue 2 - p 239-245

doi: 10.1097/SLA.0000000000005476

Keywords:

Aijtink, Virginia J, Rutten, Vera C. Meijer, Beatrice E.M. de Jong, Renate Isaac, John L. Polak, Wojciech Perera, M. Thamara P.R. MD, FRCS§,∥; Sneiders, Dimitri Hartog, Hermien, Safety, Intraoperative Blood, Salvage, Liver, Transplantation, Patients, Hepatocellular, Carcinoma, Systematic, Review, Meta-analysis, Annals of Surgery

Annals of SurgeryHepatocellular CarcinomaLiver TransplantationIntraoperative Blood Salvage

Source : Annals of surgery

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751