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  • Intraoperative opioid...

Intraoperative opioid dosing based on the NOL index significantly reduces post-operative pain

Written By : Dr. Kamal Kant Kohli Published On 2023-03-16T09:45:43+05:30  |  Updated On 16 March 2023 12:36 PM IST
Intraoperative opioid dosing based on the NOL index significantly reduces post-operative pain
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The odds of experiencing severe pain in the post-anesthesia care unit (PACU) is six times lower with Nociception Level (NOL) guided intraoperative analgesia compared to standard of care monitoring.

A new study, which pooled data from two randomized clinical trials (Meijer et al 2020, Fuica et al 2022), found that intraoperative opioid dosing based on the NOL index reduced the proportion of patients reporting severe pain by 70% and improved PACU pain scores by a median of 1.5 NRS points at 90 minutes post surgery. Additionally, NOL guidance was the only significant factor explaining the difference in the number of patients experiencing severe pain (OR 5.98, p=0.02).

“The study shows that how NOL monitoring can help minimize the prevalence of severe pain after surgery and all of its negative repercussions,” says Prof. Albert Dahan, who led the study. “This represents an important benefit of nociception monitoring to patients and clinicians alike”.

Medasense's NOL technology uses machine learning algorithms to continuously monitor patients during surgery, providing real-time information on nociception levels, personalizing dosing of analgesics to the patients’ actual requirements. Earlier studies have shown that the NOL index outperforms other indexes for monitoring of pain response to surgical stimuli and that NOL-guided analgesia resulted in reduced intraoperative opioid consumption, leading to fewer intraoperative hypotensive events.

The new study, just published in Frontiers of Pain Research1 pooled data from two published trials with a similar protocol, analysing data from 125 patients – 61 of which received NOL-guided fentanyl dosing and 64 standard care.2,3 The patients were randomly divided so that one group received NOL-guided analgesia dosing during the surgery and the control group received analgesics according to standard of care (based on hemodynamic monitoring). The study showed that while there was no difference in intraoperative fentanyl consumption between the groups, the patients in the NOL-guided group reported less pain in the first 90 minutes compared to the control arm.

“We are thrilled to see the results of this study and the positive impact our technology is having on patients” says Galit Zuckerman-Stark, CEO & Founder of Medasense, “Our goal is to improve the lives of patients by improving their pain management, and these findings demonstrate the potential of NOL to do just that”.

Reference:

Imeen van der Wal, Fleur Meijer, Rivka Fuica, Zmira Silman, Martijn Boon, Chris Martini, Monique van Velzen, Albert Dahan, Marieke Niesters and Yaacov Gozal https://doi.org/10.3389/fpain.2022.1086862

Frontiers in Pain Researchpost-operative painNociception Levelopioidsurgery
Source : Frontiers in Pain Research
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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