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  • ketorolac increases...

ketorolac increases risk of anastomotic leak after colorectal surgery

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-03-17T09:00:39+05:30  |  Updated On 17 March 2022 9:00 AM IST
ketorolac increases risk of anastomotic leak after colorectal surgery
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The use of ketorolac increases the risk of anastomotic leak after colorectal surgery, according to a recent study published in the Frontiers in Surgery.

This meta-analysis aimed to evaluate whether ketorolac administration is associated with an increased anastomotic leak rate after colorectal surgery.

The literature was searched using the Web of Science, Embase, and PubMed databases, and the search ended on May 31, 2020. The Newcastle–Ottawa Scale was used to assess methodological quality. Statistical heterogeneity was assessed using the Chi-square Q test and I2 statistics. Subgroup analysis was performed, and Egger's test was used to assess publication bias.

Results:

This meta-analysis included seven studies with 400,822 patients. Our results demonstrated that ketorolac administration after surgery increases the risk of anastomotic leak [OR = 1.41, 95% CI: 0.81–2.49, Z = 1.21, P = 0.23]. Low heterogeneity was observed across these studies (I2 = 0%, P = 0.51). The results of subgroup analysis showed that the use of ketorolac in case–control and retrospective cohort studies significantly increased the risk of anastomotic leak (P < 0.05). Furthermore, the subgroup analysis revealed that ketorolac use increased anastomotic leak rate in patients in the United States and Canada, and ketorolac plus morphine use did not increase anastomotic leak rate in Taiwanese patients (P < 0.05). No significant publication bias was observed (P = 0.126). Moreover, the analysis of risk factors related to anastomotic leak rate indicated that the total use of ketorolac did not increase the risk of anastomotic leak similar to the control group (P > 0.05).

Thus, the researchers concluded that the meta-analysis indicates that the use of ketorolac increases the risk of anastomotic leak after colorectal surgery.

Reference:

Ketorolac Administration After Colorectal Surgery Increases Anastomotic Leak Rate: A Meta-Analysis and Systematic Review by Wen Chen et al. published in the Frontiers in Surgery.

https://www.frontiersin.org/articles/10.3389/fsurg.2022.652806/full

Keywords:

Wen Chen, Jing Liu, Yongqiang Yang, Yanhong Ai, and Yueting Yang, Ketorolac Administration for colorectal surgery, Colorectal Surgery Increases Anastomotic Leak Rate, Frontiers in Surgery, Colorectal Surgery and Anastomotic Leak Rate, Ketorolac and Colorectal Surgery


Frontiers in SurgeryAnastomotic Leak RateKetorolac AdministrationColorectal Surgery
Source : Frontiers in Surgery
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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