Pancreaticoduodenectomy improves long-term benefits of chronic pancreatitis: Frontiers

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-10-01T19:30:04+05:30 | Updated On 1 Oct 2022 7:30 PM IST

China: Major surgical procedures can effectively treat Chronic pancreatitis (CP), including pylorus-preserving pancreaticoduodenectomy (PPPD), Beger surgery, Frey's revision, and Berne's revision, says an article published in Frontiers in Surgery.

Chronic pancreatitis (CP) is a progressive, irreversible, fibroinflammatory disease characterized by persistent pancreatic parenchymal destruction and fibrosis, leading to intractable pain and decreased quality of life (QOL). As the disease advance, there is a continual loss of pancreatic function and local complications (eg, ductal obstruction, pancreatic pseudocysts, etc.). Surgery is an effective option for treating chronic pancreatitis. However, there is no clear consensus on the best choice for surgical procedures. Therefore, Yu Mou and his team aimed to conduct a network meta-analysis of randomized controlled trials comparing treatment outcomes to provide high-quality evidence on which surgery is best for his CP.

The main results of this study were:

1. Ten studies with a total of 680 patients were identified for inclusion.

2. PPPD was associated with superior short-term postoperative pain relief and quality of life (QOL), but exacerbated pancreatic exocrine dysfunction and high morbidity.

3. Bern had significantly higher long-term postoperative pain relief and mortality, and a lower risk of exocrine pancreatic insufficiency.

In summary, major surgical procedures, including PPPD, Beger's surgery, Frey's revision, and Berne's revision, can effectively treat CP in the short term as well as the long term. Also, Berner's method is simpler than his PPPD and Beger's method. However, burner modification may reduce postoperative QOL. In our experience, PPPD or classic pancreatoduodenectomy should be the only legitimate option if a CP patient has a mass indistinguishable from pancreatic cancer in the pancreatic head.

Reference:

Mou, Y., Song, Y., Chen, H.-Y., Wang, X., Huang, W., Liu, X.-B., & Ke, N.-W. (2022). Which Surgeries Are the Best Choice for Chronic Pancreatitis: A Network Meta-Analysis of Randomized Controlled Trials. In Frontiers in Surgery (Vol. 8). Frontiers Media SA. https://doi.org/10.3389/fsurg.2021.798867

chronic pancreatitisFrontiers in SurgeryPancreaticoduodenectomy

Source : Frontiers in Surgery

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751