Plication transoral outlet reduction effectively treats weight regain after RYGB: Study
Plication transoral outlet reduction (P-TORe) is effective in treating weight regain after Roux-en-Y gastric bypass (RYGB), according to a recent study published in the Gastrointestinal Endoscopy.
Gastric Plication involves inverting the stomach with tissue anchor placement to achieve serosa to serosa apposition. One potential application of gastric plication is the treatment of weight regain following Roux-en-Y gastric bypass (RYGB), a procedure also known as plication transoral outlet reduction (P-TORe). This study aims to assess the technical feasibility, safety and efficacy of Plication transoral outlet reduction (P-TORe).
This was a registry study of Roux-en-Y gastric bypass (RYGB) patients who underwent Plication transoral outlet reduction (P-TORe) for weight regain. The primary outcome was the amount of weight loss and clinical success rate, defined as per cent total weight loss (%TWL) of at least 5%, at 12 months. Secondary outcomes included technical success, adverse events (AEs) and predictors of weight loss.
The results of the study are:
111 RYGB patients underwent Plication transoral outlet reduction (P-TORe). The average BMI was 38.5±7.5 kg/m2. Baseline GJA and pouch sizes were 17±6 mm and 5±2 cm, respectively. Primary Outcome: At 12 months, patients experienced 9.5±8.5% TWL. The clinical success rate was 73%. Secondary Outcomes: Technical success rate was 100%. Argon plasma coagulation (APC) was performed around the GJA in all patients (100%) prior to plication placement. The total number of plications per case was 7±3. Overall AE rate was 12.6%. These included GJA stenosis (9.9%), melena due to marginal ulceration (1.8%) and deep vein thrombosis (0.9%). The severe AE rate was 0%. Predictors of weight loss where the amount of weight regain and baseline pouch length.
Thus, this novel Plication transoral outlet reduction (P-TORe) technique combining APC with gastric plication appears technically feasible, safe and effective at treating weight regain following RYGB.
Reference:
Endoscopic Gastric Plication for the Treatment of Weight Regain Following Roux-en-Y Gastric Bypass by Pichamol Jirapinyo et al. published in the Gastrointestinal Endoscopy.
DOI: https://doi.org/10.1016/j.gie.2022.02.051
