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  • Study shows negative...

Study shows negative impact of smoking on outcomes of varicocelectomy

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-01-31T17:00:00+05:30  |  Updated On 31 Jan 2024 5:00 PM IST
Study shows negative impact of smoking on outcomes of varicocelectomy
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Turkey: A retrospective cohort study published in International Urology and Nephrology has shown the negative effect of smoking on varicocelectomy outcomes concerning semen parameters, spontaneous pregnancy development and timing.

A varicocelectomy is a surgical procedure for varicocele treatment. It can lower testicular pain and can increase male fertility. Risks include bruising, swelling and injury to the testicular artery. Most people fully recover from a varicocelectomy within six weeks.

Previous studies have shown that in men with varicocele, a major cause of male infertility, smoking is associated with decreased sperm functional integrity, altered semen quality, and seminal oxidative stress

Tugay Aksakalli, Erzurum Regional Training and Research Hospital, Erzurum, Turkey, and colleagues aimed to evaluate the effects of smoking on semen parameters and spontaneous pregnancy development by comparing smoker and non-smoker varicocelectomy patients. The study included 63 male patients with primary infertility for at least one year who underwent microscopic subinguinal varicocelectomy at the Erzurum City Hospital urology clinic between 2020 and 2023.

The researchers retrospectively evaluated the patient files, 27 patients were assigned to the smoker group, whereas 36 patients were assigned to the non-smoker group. Semen parameters, demographic data, spontaneous pregnancy development and timing were compared between the two groups.

Based on the study, the following inferences were drawn:

· No statistically significant differences were observed in age, partner's age, BMI, clinical presentation, varicocele grade, side of varicocele, testicular volume, or testicular vein diameters. The mean age of the study group was determined to be 30.7 ± 4.9 years.

· In the non-smoker group, 75% of patients had only subfertility complaints, while 25% of patients also experienced scrotal pain.

· Progressive motility was significantly higher in the non-smoker group in the 3rd month (28.11 ± 5.78 vs. 24.51 ± 4.24) and 6th month (29.61 ± 5.16 vs. 26.22 ± 4.14) evaluations.

· When comparing the rates of pregnancy development, the non-smoker group was determined to have a higher rate (53%), but this comparison was not statistically significant.

· Regarding the timing of pregnancy, the non-smoker group was associated with earlier spontaneous pregnancy. (5.84 ± 2.26 vs. 9.20 ± 2.30).

"Smoking negatively affects the outcomes of varicocelectomy in terms of spontaneous pregnancy development, timing, and semen parameters," the researchers wrote.

"There is a need for prospective, randomized, and larger sample-sized studies on this subject," they concluded.

Reference:

Aksakalli, T., Utlu, A., Demirdogen, S.O. et al. Effects of smoking on varicocelectomy outcomes: a retrospective cohort study. Int Urol Nephrol 56, 415–421 (2024). https://doi.org/10.1007/s11255-023-03816-6


International Urology and Nephrologyvaricocelectomyvaricocelesmokingspontaneous pregnancysemen
Source : International Urology and Nephrology
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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